동의신경정신과학회지 (Journal of Oriental Neuropsychiatry)

  • 제23권2호
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  • Pages.121-128
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  • 2012
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  • 1226-6396(pISSN)
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  • 2234-4942(eISSN)
대한한방신경정신과학회 (The Korean Society of Oriental Neuropsychiatry)
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ACM의 Sprague-Dawley Rat 경구 단회 투여 독성시험

Single Oral Dose Toxicity Test of ACM(Added Chongmyung-tang) in Sprague-Dawley Rat

  • 최우창 (대전대학교 한의과대학 신경정신과학교실) ;
  • 정인철 (대전대학교 한의과대학 신경정신과학교실) ;
  • 임종순 (대전대학교 한의과대학 생명예방과학교실) ;
  • 김승형 (대전대학교 동서생명과학연구원) ;
  • 이상룡 (대전대학교 한의과대학 생명예방과학교실)
  • Choi, Woo-Chang (Dept. of Neuropsychiatry, College of Oriental Medicine, Daejeon University) ;
  • Jung, In-Chul (Dept. of Neuropsychiatry, College of Oriental Medicine, Daejeon University) ;
  • Lim, Jong-Soon (Dept. of Life Science and Preventative Medicine College of Oriental Medicine, Dae-Jeon University) ;
  • Kim, Seung-Hyung (Institute of Traditional Medicine and Bioscience, Dae-Jeon University) ;
  • Lee, Sang-Ryong (Dept. of Life Science and Preventative Medicine College of Oriental Medicine, Dae-Jeon University)
  • 투고 : 2012.05.25
  • 심사 : 2012.06.21
  • 발행 : 2012.06.30
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초록

Objectives : This research investigates the single oral dose toxicity of ACM in SD rats. Methods : ACMs were administered to female and male SD rats, as an oral dose of 5000 mg/kg. Animals were monitored for the mortality and changes in the body weight, clinical signs and gross observation during the 14 days after dosing, upon necropsy. Results : We could not find any mortality. Compared with the control group, significant weight change was not observed in the experimental group. First day after administration, compound-colored stool was observed in all rats. After the second day of administration, the more common symptoms were not observed. There were no gross abnormalities in all cases. [ED NOTE: highlight: given the context, this is very vague] Conclusions : The results obtained in this study suggest that the approximate lethal dose of ACM in both female and male rats were considered as over 5000 mg/kg.

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