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C57BLKS/J-db/db 마우스에서 흑삼의 당뇨 합병증 개선 효과

Ameliorative Effect of Black Ginseng on Diabetic Complications in C57BLKS/J-db/db Mice

  • 김애정 (경기대학교 대체의학대학원 대체의학과) ;
  • 유현숙 (경기대학교 대체의학대학원 대체의학과) ;
  • 강신정 (중부대학교 한약자원학과)
  • Kim, Ae-Jung (The Graduate School of Alternative Medicine, Kyonggi University) ;
  • Yoo, Hyun-Sook (The Graduate School of Alternative Medicine, Kyonggi University) ;
  • Kang, Shin-Jung (Dept. of Medicine Resources, Graduate School of Jungboo University)
  • 투고 : 2012.01.13
  • 심사 : 2012.02.15
  • 발행 : 2012.03.31

초록

The goal of this study was to examine the ameliorative effects of black ginseng(BG) in male obese diabetic C57BLKS/ J-db/db mice. Ten-week-old male db/db mice were administrated 300 mg/kg of F-BG daily for 6 weeks, The db/db mice where corresponded to the normal group and db/db mice which were the diabetic positive group were not provided BG treatment. The supressive effects of treatment were examined on serum lipids levels, which included total cholesterol, triglyceride, LDL-cholesterol and nonesterified fatty acid. Also, weight changes and the relative weight of liver and kidney, organ pathological investigation were measured. The effects of treatment were assessed by comparing the results of the db/db mice that received BG for 6 weeks with that of the diabetic positive group. Significant differences in several biological parameters such as HDL level(p<0.05), TG level(p<0.05) and NEFA level(p<0.05) were observed for the BG group. BG treatment increased the HDL level and decreased the NEFA level, which could ameliorate hyperlipidemia or blood circulation.

키워드

참고문헌

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피인용 문헌

  1. The Anti-Diabetic Effects and Nephroprotective Effect of Black Ginseng Prosapogenin Extract in Streptozotocin-Induced Mice vol.24, pp.2, 2016, https://doi.org/10.7783/KJMCS.2016.24.2.115
  2. Effects of ramie leaf extract on blood glucose and lipid metabolism in db/db mice vol.57, pp.5, 2014, https://doi.org/10.1007/s13765-014-4193-y
  3. Black Ginseng and Its Saponins: Preparation, Phytochemistry and Pharmacological Effects vol.24, pp.10, 2012, https://doi.org/10.3390/molecules24101856
  4. 고려인삼과 당뇨병: 세포와 동물 및 인체실험을 통한 고려인삼의 당뇨병에 대한 효능 vol.51, pp.1, 2012, https://doi.org/10.22889/kjp.2020.51.1.001
  5. 흑삼 및 흑마늘을 이용한 블랙잼 유동특성 모니터링 vol.37, pp.2, 2012, https://doi.org/10.12925/jkocs.2020.37.2.183