The Korean Journal of Food And Nutrition (한국식품영양학회지)

The Korean Society of Food and Nutrition (한국식품영양학회)
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Ameliorative Effect of Black Ginseng on Diabetic Complications in C57BLKS/J-db/db Mice

C57BLKS/J-db/db 마우스에서 흑삼의 당뇨 합병증 개선 효과

  • Kim, Ae-Jung (The Graduate School of Alternative Medicine, Kyonggi University) ;
  • Yoo, Hyun-Sook (The Graduate School of Alternative Medicine, Kyonggi University) ;
  • Kang, Shin-Jung (Dept. of Medicine Resources, Graduate School of Jungboo University)
  • 김애정 (경기대학교 대체의학대학원 대체의학과) ;
  • 유현숙 (경기대학교 대체의학대학원 대체의학과) ;
  • 강신정 (중부대학교 한약자원학과)
  • Received : 2012.01.13
  • Accepted : 2012.02.15
  • Published : 2012.03.31
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Abstract

The goal of this study was to examine the ameliorative effects of black ginseng(BG) in male obese diabetic C57BLKS/ J-db/db mice. Ten-week-old male db/db mice were administrated 300 mg/kg of F-BG daily for 6 weeks, The db/db mice where corresponded to the normal group and db/db mice which were the diabetic positive group were not provided BG treatment. The supressive effects of treatment were examined on serum lipids levels, which included total cholesterol, triglyceride, LDL-cholesterol and nonesterified fatty acid. Also, weight changes and the relative weight of liver and kidney, organ pathological investigation were measured. The effects of treatment were assessed by comparing the results of the db/db mice that received BG for 6 weeks with that of the diabetic positive group. Significant differences in several biological parameters such as HDL level(p<0.05), TG level(p<0.05) and NEFA level(p<0.05) were observed for the BG group. BG treatment increased the HDL level and decreased the NEFA level, which could ameliorate hyperlipidemia or blood circulation.

Keywords

References

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