한국약용작물학회지 (Korean Journal of Medicinal Crop Science)

  • 제20권2호
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  • Pages.94-100
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  • 2012
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  • 1225-9306(pISSN)
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  • 2288-0186(eISSN)
한국약용작물학회 (The Korean Society of Medicinal Crop Science)
권호 표지
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구아바 잎 열수추출물의 당류분해효소 저해 효과 및 OGTT에 미치는 효과

Effect of Aqueous Extract of Guava (Psidium guajava L.) Leaves on the Oral Glucose Tolerance Test and Inhibition of Glycoside Hydrolase

  • 최수민 ((주) 이롬 생명과학연구원) ;
  • 김중학 ((주) 이롬 생명과학연구원) ;
  • 정지상 ((주) 이롬 생명과학연구원) ;
  • 김화영 ((주) 이롬 생명과학연구원) ;
  • 장혜은 ((주) 이롬 생명과학연구원) ;
  • 황성주 ((주) 이롬 생명과학연구원) ;
  • 홍성길 ((주) 이롬 생명과학연구원)
  • 투고 : 2012.01.27
  • 심사 : 2012.04.02
  • 발행 : 2012.04.30
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초록

Guava ($Psidium$ $guajava$) contain a great deal of polyphenol compound and work on the treatment of $Diabetes$ $mellitus$ effectively. In this study, the bioactivities of aqueous extract (GLEx) of guava leaf were investigated. Total phenolic contents of GLEx was 266.9 mg tan/g. The effects of GLEx on digestive enzymes, ${\alpha}$-amylase, maltase and sucrase were investigated. $IC_{50}$ values of GLEx against ${\alpha}$-amylase, maltase and sucrase were 0.65 mg/$m{\ell}$, 2.0 mg/$m{\ell}$ and 3.5 mg/$m{\ell}$ respectively. The effect of GLEx on oral glucose tolerance test (OGTT) was performed in normal ICR mouse, control (dstilled water) and GLEx (aqueous extract of Guava leaf) were co-administered orally with glucose, showed reducing effect on the blood glucose level. The guava is likely to useful for prevention or improvement of hyperglycemia by lowering the blood glucose level and inhibiting glycoside hydrolase activity.

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  1. Quality Characteristics of Dinner Roll Added with Lyophilized Sweet Potato Powder and Its Effect on the Blood Glucose Level vol.45, pp.1, 2013, https://doi.org/10.9721/KJFST.2013.45.1.40