The Korean Journal of Medicine

The Korean Association of Internal Medicine (대한내과학회)
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Two Cases of Hyponatremia Induced by Duloxetine for Treating Peripheral Neuropathic Pain

말초신경병증 통증 치료를 위해 투여한 Duloxetine 유발 저나트륨혈증 2예

  • Ra, Ji Eun (Department of Internal Medicine, Sanbon Hospital, Wonkwang University College of Medicine) ;
  • Hwang, In Kyeom (Department of Internal Medicine, Sanbon Hospital, Wonkwang University College of Medicine) ;
  • Seo, Bong Soo (Department of Internal Medicine, Sanbon Hospital, Wonkwang University College of Medicine) ;
  • Lee, Ji Kyoung (Department of Internal Medicine, Sanbon Hospital, Wonkwang University College of Medicine) ;
  • Mok, Young Mi (Department of Internal Medicine, Sanbon Hospital, Wonkwang University College of Medicine) ;
  • Kim, Hyunwook (Department of Internal Medicine, Sanbon Hospital, Wonkwang University College of Medicine) ;
  • Lee, Ji Eun (Department of Internal Medicine, Sanbon Hospital, Wonkwang University College of Medicine)
  • 라지은 (원광대학교 의과대학 산본병원 내과) ;
  • 황인겸 (원광대학교 의과대학 산본병원 내과) ;
  • 서봉수 (원광대학교 의과대학 산본병원 내과) ;
  • 이지경 (원광대학교 의과대학 산본병원 내과) ;
  • 목영미 (원광대학교 의과대학 산본병원 내과) ;
  • 김현욱 (원광대학교 의과대학 산본병원 내과) ;
  • 이지은 (원광대학교 의과대학 산본병원 내과)
  • Published : 2012.12.01
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Abstract

Duloxetine is a balanced serotonin and norepinephrine reuptake inhibitor available for treating peripheral neuropathic pain. The occurrence of hyponatremia as an adverse event of duloxetine treatment, but it has not yet been reported in Korea. Here, we report two cases of hyponatremia induced by duloxetine for treatment of peripheral neuropathic pain. Our findings highlight the need for special attention when using duloxetine in elderly patients taking thiazide diuretics.

Duloxetine은 당뇨병성 말초신경병증 통증 치료를 위해 최근 처방 빈도가 증가하고 있는 세로토닌 노르에피네프린 재흡수 억제제로 저나트륨혈증을 일으킬 수 있으나 아직까지 국내에서는 보고된 바가 없다. 저자들은 duloxetine 복용과 연관된 저나트륨혈증 2예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

Keywords

References

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