DOI QR코드

DOI QR Code

Modeling of Hemodynamics in Stenosed Artery

협착 동맥혈관의 혈류유동 모델링

  • Kim, Seong-Jong (Division of Chemical Engineering, Chonbuk National University) ;
  • Park, Young-Ran (Division of Chemical Engineering, Chonbuk National University) ;
  • Kim, Shagn-Jin (Department of Pharmacology, College of Veterinary Medicine, Korea Zoonosis Research Institute, Chonbuk National University) ;
  • Kang, Hyung-Sub (Department of Pharmacology, College of Veterinary Medicine, Korea Zoonosis Research Institute, Chonbuk National University) ;
  • Kim, Jin-Shang (Department of Pharmacology, College of Veterinary Medicine, Korea Zoonosis Research Institute, Chonbuk National University) ;
  • Oh, Sung-Hoon (Division of Mechanical System Engineering, Chonbuk National University) ;
  • Kang, Sung-Jun (Division of Mechanical System Engineering, Chonbuk National University) ;
  • Kim, Gi-Beum (Department of Pharmacology, College of Veterinary Medicine, Korea Zoonosis Research Institute, Chonbuk National University)
  • 김성종 (전북대학교 화학공학부) ;
  • 박영란 (전북대학교 화학공학부) ;
  • 김상진 (전북대학교 수의과대학 약리학교실.인수공통전염병연구소) ;
  • 강형섭 (전북대학교 수의과대학 약리학교실.인수공통전염병연구소) ;
  • 김진상 (전북대학교 수의과대학 약리학교실.인수공통전염병연구소) ;
  • 오성훈 (전북대학교 기계시스템공학부) ;
  • 강성준 (전북대학교 기계시스템공학부) ;
  • 김기범 (전북대학교 수의과대학 약리학교실.인수공통전염병연구소)
  • Received : 2012.03.05
  • Accepted : 2012.05.10
  • Published : 2012.05.31

Abstract

This study is about atherosclerosis which occupies the highest rate in many diseases people have and we have studied about atherosclerosis for abdominal aorta. Atherosclerosis is the phenomenon which blood vessel gets narrower, harder and thicker due to the stenosis of colesterol in blood vessel. If it becomes worse, arteries will be hard and blood can't flow smoothly, and even it can reach to death. In this study, the geometric models of the considered stenotic blood flow are two different types of constriction of cross-sectional area of blood vessel; 20 and 45% of constriction in each elastic wall and rigid wall. We have modeled by using finite element method to observe the changes of velocity and pressure. In case of the diameter of blood vessel decreased 45% in elastic wall model, the values of velocity and pressure were higher than the case of 20% and in case of the diameter of blood vessel decreased 45% in rigid wall model, the values of velocity and pressure were higher than the case of 20%. In cases of elastic wall models of the diameters of blood vessels decreased each of 20% and 45%, recirculation zones appeared. This results show understanding of hemodynamic properties depending on stenosed blood vessels.

동맥경화는 혈관 안에서 콜레스테롤의 침착 때문에 혈관이 좁아지거나, 딱딱해 지거나, 두꺼워 지게 되는데, 이런 현상이 심해지게 되면 동맥은 단단해져서 혈액이 원활히 통과하지 못하게 되고 심하면 사망 까지 이르게 되는 것이다. 본 연구에서는 복대동맥에서의 동맥경화가 진행되는 것을 탄성 혈관 일 때와 강성 혈관 일 때 각각 협착률이 혈관 직경의 20과 45%로 설정하고 속도와 압력 변화를 살펴보기 위하여 유한 요소 해석을 이용하여 모델링을 하였다. 혈관이 탄성 혈관일 때 속도와 압력 값은 협착률이 혈관 직경의 20%일 때 보다 45%일 때 더 높게 나타났으며, 강성 혈관에서 속도와 압력 값은 협착률이 혈관 직경의 20%일 때보다 45%에서 더 높았다. 협착률이 혈관 직경의 20과 45%인 탄성 혈관에서 재순환영역이 나타났다. 본 연구결과 혈관 협착에 따른 혈류역학적 특징을 이해하는데 도움이 될 것으로 판단된다.

Keywords

References

  1. H. S. Kim, "A intelligible story of hypertension and heart disease", Koonja, pp.3-90, 2010.
  2. N. B. Lee, et al., "Development of a Pulse Wave Velocity Measurement System and Assessment of the System Reproducibility for the Diagnosis of Arteriosclerosis", Korean J. Institute of Oriental Medical Diagnostics, 9(1), pp.112-124, 2005.
  3. L. Jiang, et al., "On the blow up criterion for the 2-D compressible Navier-Stokes equations", Czechoslovak Math. J, 60(1), pp.195-209, 2010. https://doi.org/10.1007/s10587-010-0009-3
  4. S. H. Suh, et al., "Correlation between atherosclerosis and geometrical characteristic changes of blood vessels", Biomedical Engineering Society for Circulatory Disorders Semiannual 5th conference, 2005.
  5. M. S. Park, et, al., "Numerical analysis of the blood flow in the korean artificial heart using two dimensional model", Korean J. Biomedical and biological engineering, 24(4), pp.301-307, 2003.
  6. H. K. Kim, et. al., "The relationship between aortic distensibility and serologic markers of atherosclerosis", J. Internal medicine, 77(1), pp.68-75, 2009.
  7. S. D. Jung, et. al., "A Numerical Analysis on the Hemodynamic Characteristics in Elastic Blood Vessel with Stenosis", J. Biomed. Eng, 23(4), pp.281-286, 2002.
  8. G. H. Kwon, et. al., "Insulin Sensitivty is Associated with the Presence and Extent of Coronary Artery Disease", Korea circulation Journal, 32(7), pp.566-572, 2002. https://doi.org/10.4070/kcj.2002.32.7.566
  9. T. W. Tae, B. Buriev, "Numerical study of pulsatile blood flow in stenotic artery", J. KSME, 32(11), pp.891-896, 2008. https://doi.org/10.3795/KSME-B.2008.32.11.891