Journal of Korean Society for Clinical Pharmacology and Therapeutics (임상약리학회지)

Korean Society for Clinical Pharmacology and Therapeutics (대한임상약리학회)
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Retrospective Analysis of Adverse Reactions to Iodinated Contrast Media in Korean

한국인에서 요오드성 영상조영제 이상반응의 후향적 분석

  • Kim, Hee Hyun (Department of Pharmacology, Inje University College of Medicine) ;
  • Choi, Ji Yeob (Department of Biomedical Sciences, Seoul National University College of Medicine) ;
  • Oh, Min Kyung (Department of Pharmacology, Inje University College of Medicine) ;
  • Kim, Eun Young (Department of Clinical pharmacology, Inje University Busanpaik Hospital) ;
  • Ghim, Jong Ryul (Department of Clinical pharmacology, Inje University Busanpaik Hospital) ;
  • Choi, Seok Jin (Department of Radiology, Inje University Busanpaik Hospital) ;
  • Shin, Jae Gook (Department of Pharmacology, Inje University College of Medicine)
  • 김희현 (인제대학교 의과대학 약리학교실) ;
  • 최지엽 (서울대학교 의과대학 의과학과) ;
  • 오민경 (인제대학교 의과대학 약리학교실) ;
  • 김은영 (인제대학교 부산백병원 임상약리학과) ;
  • 김종률 (인제대학교 부산백병원 임상약리학과) ;
  • 최석진 (인제대학교 부산백병원 영상의학과) ;
  • 신재국 (인제대학교 의과대학 약리학교실)
  • Received : 2012.11.12
  • Accepted : 2012.12.14
  • Published : 2012.12.31
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Abstract

Background: This study was performed to evaluate the prevalence and risk factors on the adverse reactions caused by iodinated contrast media (CM) for computed tomography (CT) examination in a university hospital. Methods: Clinical and demographic data among outpatients with CM use were collected at 0000 University Busanpaik Hospital in Busan, Korea between 2008 and 2010. Adverse reaction rate was calculated by the number of adverse reaction among total outpatients with CM use, which was stratified by seasons and sex. The association of risk factors on adverse reaction was investigated using logistic regression model. Results: The total outpatients and events of administered CMs were 27,587 and 48,616, respectively. The administered CMs were iopromide, iohexol, iobitridol, and iodixanol. Adverse reactions occurred in 300 outpatients among the total outpatients (1.1 %). The number of outpatients administered CM more than twice were 8,348. Among them, outpatients who experienced adverse reaction(s) more than once and twice were 124 (1.5 %) and 26 (0.3 %), respectively. Adverse reaction rate was significantly different by sex(p=0.01). The other risk factors were cancer history (OR 2.57, 95 % CI 2.00-3.31) and previous CM administration (OR 1.89, 95 % CI 1.47-2.44). Urticaria was the most frequent symptoms. Conclusion: Total adverse reaction rate was 1.1 % with most common symptom in skin system. Related risk factors were female, cancer history, and previous CM administration. These results were similar to previous studies and will be contribute to clinical practice and future research especially in Koreans.

Keywords

Acknowledgement

Supported by : 한국연구재단

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