Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
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A Multicenter Study of Pertussis Infection in Adults with Coughing in Korea: PCR-Based Study

  • Park, Sunghoon (Division of Pulmonary, Allergy and Critical Care Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Lee, Myung-Gu (Division of Pulmonary, Allergy and Critical Care Medicine, Chuncheon Sacred Heart Hospital, Lung Research Institute of Hallym University College of Medicine) ;
  • Lee, Kwan Ho (Division of Pulmonary, Allergy and Critical Care Medicine, Yeungnam University Medical Center, Yeungnam University College of Medicine) ;
  • Park, Yong Bum (Division of Pulmonary, Allergy and Critical Care Medicine, Kangdong Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Yoo, Kwang Ha (Division of Pulmonary, Allergy and Critical Care Medicine, Konkuk University Hospital, Konkuk University School of Medicine) ;
  • Park, Jeong-Woong (Division of Pulmonary and Critical Care Medicine, Gachon University Gil Hospital, Gachon University of Medicine and Science) ;
  • Kim, Changhwan (Division of Pulmonary and Critical Care Medicine, Sejong General Hospital) ;
  • Lee, Yong Chul (Division of Pulmonary, Allergy and Critical Care Medicine, Chonbuk National University Hospital, Chonbuk National University Medical School) ;
  • Park, Jae Seuk (Division of Pulmonary, Allergy and Critical Care Medicine, Dankook University Hospital, Dankook University College of Medicine) ;
  • Kwon, Yong Soo (Division of Pulmonary and Critical Care Medicine, Chonnam National University Hospital, Chonnam National University Medical School) ;
  • Seo, Ki-Hyun (Division of Pulmonary, Allergy and Critical Care Medicine, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine) ;
  • Kim, Hui Jung (Division of Pulmonary and Critical Care Medicine, Wonkwnag University Sanbon Hospital, Wonkwang University School of Medicine) ;
  • Kwak, Seung Min (Division of Pulmonary and Critical Care Medicine, Inha University Hospital, Inha University School of Medicine) ;
  • Kim, Ju-Ock (Division of Pulmonary and Critical Care Medicine, Chungnam National University Hospital, Chungnam National University School of Medicine) ;
  • Lim, Seong Yong (Division of Pulmonary and Critical Care Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine) ;
  • Sung, Hwa-Young (Division of Bacterial Respiratory Infection, Korea National Institute of Health, Korea Centers for Disease Control and Prevention) ;
  • Jung, Sang-Oun (Division of Bacterial Respiratory Infection, Korea National Institute of Health, Korea Centers for Disease Control and Prevention) ;
  • Jung, Ki-Suck (Division of Pulmonary, Allergy and Critical Care Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine)
  • Received : 2012.03.19
  • Accepted : 2012.10.26
  • Published : 2012.11.30
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Abstract

Background: Limited data on the incidence and clinical characteristics of adult pertussis infections are available in Korea. Methods: Thirty-one hospitals and the Korean Centers for Disease Control and Prevention collaborated to investigate the incidence and clinical characteristics of pertussis infections among adults with a bothersome cough in non-outbreak, ordinary outpatient settings. Nasopharyngeal aspirates or nasopharyngeal swabs were collected for polymerase chain reaction (PCR) and culture tests. Results: The study enrolled 934 patients between September 2009 and April 2011. Five patients were diagnosed as confirmed cases, satisfying both clinical and laboratory criteria (five positive PCR and one concurrent positive culture). Among 607 patients with cough duration of at least 2 weeks, 504 satisfied the clinical criteria of the US Centers for Disease Control and Prevention (i.e., probable case). The clinical pertussis cases (i.e., both probable and confirmed cases) had a wide age distribution ($45.7{\pm}15.5$ years) and cough duration (median, 30 days; interquartile range, 18.0~50.0 days). In addition, sputum, rhinorrhea, and myalgia were less common and dyspnea was more common in the clinical cases, compared to the others (p=0.037, p=0.006, p=0.005, and p=0.030, respectively). Conclusion: The positive rate of pertussis infection may be low in non-outbreak, ordinary clinical settings if a PCR-based method is used. However, further prospective, well-designed, multicenter studies are needed.

Keywords

References

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