Screening of Antioxidative Activities and Antiinflammatory Activities in Local Native Plants

국내자생식물 추출물의 항산화 및 항염 활성 탐색

  • Received : 2012.01.13
  • Accepted : 2012.03.06
  • Published : 2012.03.31

Abstract

181 kinds of local native plants were selected by its anti-inflammatorial folk medicinal uses and evaluated it antioxidative and inhibitory activity of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced 264.7 macrophage cells. Among the 181 kinds of plants, 99 species showed potent antioxidative activities and 20 extracts showed inhibitory activity towards nitric oxide production by more than 70% at a concentration of $100{\mu}g/mL$. Therefore, these plants should be considered promising candidates for the treatment of inflammatory diseases accompanying overproduction of NO.

Keywords

References

  1. Halliwell, B. (1996) Antioxidant in human health and disease. Annu. Rev. Nutr. 16: 33-49. https://doi.org/10.1146/annurev.nu.16.070196.000341
  2. Morrissey, P. A. and O'brien, N. M. (1998) Dietary antioxidants in health and disease. Int. Dairy. J. 8: 463-472. https://doi.org/10.1016/S0958-6946(98)00070-3
  3. Valko, M., Leibfritz, D., Moncol, J., Cronin, M. T., Mazur, M. and Telser, J. (2007) Free radicals and antioxidants in normal physiological functions and human disease. Int. J. Biochem. Cell. Biol. 39: 44-84. https://doi.org/10.1016/j.biocel.2006.07.001
  4. Nathan, C. F. and Hibbs, H. B. Jr., (1991) Role of nitric oxide synthesis in macrophage antimicrobial activity. Curr. Opinion. Immunol. 3: 65-70. https://doi.org/10.1016/0952-7915(91)90079-G
  5. Lee, B. H., Baik, D. S., yun, S. U., Shin, J. M., Kim, J. H., Yun, S. Y., Kim, B. H., Kim, S. B., Shin, J. E. and Song, I. H. (2007) Peripheral nitric oxide activity in patients with Liver cirrhosis. Korean. J. Med. 73: 251-257.
  6. Mu, M. M., Chakravortty, D., Sugiyama, T., Koide, N., Takahashi, K., Mori, L., Yoshida, T. and Yokochi, T. (2001) The inhibitory action of quercetin on lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophage cells. J. Endotoxin. Res. 7: 431-438.
  7. Stokes, K. Y., Cooper, D., Tailor, A. and Granger, D. N. (2002) Hypercholesterolemia promotes inflammation and microvascular dysfunction: role of nitric oxide and superoxide. Free Radical. Biol. Med. 33: 1026-1036. https://doi.org/10.1016/S0891-5849(02)01015-8
  8. Ryu, J. H., Ahn, H. Kim, J. Y. and Kim, Y. K. (2003) Inhibitory activity of plant extracts on nitric oxide synthesis in LPS-activated macrophages. Phytother. Res. 17: 485-489. https://doi.org/10.1002/ptr.1180
  9. Kim, D. H., Yi, H. S., Yun, H. J., Cha, C. M. and Park, S. D. (2010) Anti-inflammatory effect of methanol extract of Keum-Ryung-Ja-San in mouse macrophages. Kor. J. Herbology. 25: 89-98.
  10. Lin, Y. L. and Lin, J. K. (1997) (-)-Epigallocatechin 3-O-gallate blocks the induction of nitric oxide synthase by downregulating lipopolysaccharide induced activity of transcription factor nuclear factor-kappa B. Mol. Pharmacol. 52: 465-472.
  11. Tsai, S. H., Lin-Shiau, S. Y. and Lin, J, K. (1999) Suppression of nitric oxide synthase and the down-regulation of the actiation of NFkappaB in macrophages by resveratrol. Br. J. Pharmacol. 126: 673-680. https://doi.org/10.1038/sj.bjp.0702357
  12. Liang, Y. C., Huang, Y. T., Tsai, S. H., Lin-Shiau, S. Y., Chen, C. F. and Lin, J. K. (1999) Suppression of inducible cyclooxygenase and inducible nitric oxide synthase by apigenin and related flavonoids in mouse macrophage. Carcinogenesis 20: 1945-1952. https://doi.org/10.1093/carcin/20.10.1945
  13. Blois, M. S. (1958) Antioxidant determination by the use of a stable free radical. Nature 181: 1199-1200. https://doi.org/10.1038/1811199a0
  14. Fridovich, I. (1970) Quantitative aspects of the production of superoxide anion radical by milk xanthin oxidase. J. Biol. Chem. 245: 4053-4057.
  15. Feelisch, M. and Stamler, J. (1996) Methods in nitric oxide reserch. John Wiley & Sons, Chichester, 492-497.
  16. Park, S. Y., Hong, S. S., Han, X. H., Ro, J. S. and Hwang, B. Y., (2005) Inhibitory constituents of LPS-induced nitric oxide production from Arctium lappa. Nat. Prod. Sci. 11: 85-88.
  17. Kim, E. Y., Nail, I. H., Kim, J. H., Kim, S. R. and Rhyu, M. R. (2004) Screening of the antioxidant activity of some medicinal plants. Kor. J. Food. SCI. tech. 36: 333-338.
  18. Kim, J. I., Kim, H. H., Kim, S. U., Lee, K. T., Ham, I. H. and Whang, W. K. (2008) Antioxidative compounds from Quercus salicina blume stem. Arch. Pharm. Res. 31: 274-278. https://doi.org/10.1007/s12272-001-1152-2
  19. Woo, M. H., Lee, E. H., Chung, S. O. and Kim, C. W. (1996) Constituents of Spiraea prunifolia var. simpliciflora. Kor. J. Pharmacogn. 27: 389-396.
  20. Lee, M. W., Tanaka, T., Nonaka, G. and Nishioka, I. (1992) Hirsunin, an ellagitannin with a diarylheptanoid moiety from Alnus hitsuta var. micropaylla. Phytochemistry 31: 967-970.
  21. Tori, M., Hashimoto, A., Hirose, K. and Asakawa, Y. (1965) Diarylheptanoids, flavonoids, stilbenoids, sesquiterpenoids and a phenanthrene from Alnus maximowiczii. Phytochemistry 40: 1263-1264.
  22. Yamazaki, R., Aiyama, R., Matsuzaki, T., Hashimoto, S. and Yokokura, T. (1998) Anti-inflammatory effect of YPE-01, a novel diarylheptanoid derivative, on dermal inflammation in mice. Inflamm. Res. 47: 182-186. https://doi.org/10.1007/s000110050315
  23. Cho, J. Y., Sohn, M. J., Lee, J. and Kim, W. G. (2010) Isolation and identification of penta galloyl glucose with broadspectrum antibacterial activity from Rhus trichocarpa Miquel Food. Chem. 123: 501-506. https://doi.org/10.1016/j.foodchem.2010.04.072
  24. Lee, D. H., Lee, S. H., Chung, S. R., Ro, J. S. and Lee, K. S. (1995) Phenolic components from the leaves of Cornus controversa H. Kor. J. Pharmacogn. 26: 327-336.
  25. Nakaoki, T. and Morita, N. (1958) Studies on the medicinal resources. XII. Components of the leaves of Cornus controversa H. Ailanthus altissima S. and Ricinus communis L. Yakugaku Zasshi. 78: 558-559.
  26. Shaiju, K. Vareed., Robert, E. Schutzki. and Muraleedharan, G. Nair (2007) Lipid peroxidation, cyclooxygenase enzyme and tumor cell proliferation inhibitory compounds in Cornus kousa fruits. Phytomedicine 14: 706-709. https://doi.org/10.1016/j.phymed.2006.09.006