Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Cyclooxgenase Inhibitory Components from Portulaca oleracea

  • Received : 2012.01.13
  • Accepted : 2012.02.29
  • Published : 2012.03.31
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Abstract

Five triterpenoids, epifriedelanol (1), friedelin (2), lupeol (3), ${\beta}$-sitosterol (4), daucosterol (5), and one phenyl propanoids ester, trans-docosanoyl ferulate (6) were isolated from the whole parts of Portulaca oleracea. They were determined using a combination of spectroscopic analyses ($^1H-$, $^{13}C$-NMR, and MS data) and evaluated for their cyclooxygenase inhibitory activity. Compound 6 exhibited inhibitory effect with $IC_{50}$ values of $40.2{\mu}M$ and 1.6 mM on COX-1 and COX-2 activities, respectively.

Keywords

References

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