Journal of Preventive Medicine and Public Health

  • 제45권2호
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  • Pages.105-112
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  • 2012
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  • 1975-8375(pISSN)
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  • 2233-4521(eISSN)
대한예방의학회 (The Korean Society for Preventive Medicine)
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Cigarette Smoking and Serum Bilirubin Subtypes in Healthy Korean Men: The Korea Medical Institute Study

  • Jo, Jae-Seong (Institute for Health Promotion, Department of Epidemiology and Health Promotion, Yonsei University Graduate School of Public Health) ;
  • Kimm, Hee-Jin (Institute for Health Promotion, Department of Epidemiology and Health Promotion, Yonsei University Graduate School of Public Health) ;
  • Yun, Ji-Eun (Institute for Health Promotion, Department of Epidemiology and Health Promotion, Yonsei University Graduate School of Public Health) ;
  • Lee, Kyu-Jang (Korea Medical Institute) ;
  • Jee, Sun-Ha (Institute for Health Promotion, Department of Epidemiology and Health Promotion, Yonsei University Graduate School of Public Health)
  • 투고 : 2011.08.14
  • 심사 : 2011.10.17
  • 발행 : 2012.03.31
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초록

Objectives: Cigarette smoking is a modifiable risk factor for cardiovascular disease. Bilirubin is a potent antioxidant and its concentration decreases in smokers. However, studies about the association between cigarette smoking and bilirubin are scarce and most are limited to total bilirubin. Additionally, bilirubin is highly related to hemoglobin. Therefore, this study evaluates the association between bilirubin subtypes and cigarette smoking in healthy Korean men independently of hemoglobin. Methods: This study included 48 040 Korean men aged 30 to 87 years who visited the Korea Medical Institute for routine health examinations from January to December, 2007. The association of smoking with total, direct, and indirect bilirubin was assessed by logistic regression analysis taking into consideration differences in subjects and smoking characteristics. Results: Current smokers had lower bilirubin concentrations than never-smokers and ex-smokers. Smoking amount and duration were inversely significantly associated with total, direct, and indirect bilirubin. In a multivariable adjusted model, compared to never-smokers, the odds ratios (ORs) and 95% confidence intervals (CIs) of current smokers with the highest number of pack-years were 1.7 (1.6 to 1.9) for total, 1.5 (1.4 to 1.6) for direct, and 1.7 (1.6 to 1.9) for indirect bilirubin. After further adjustment for hemoglobin, this association became stronger (OR [95% CI], 2.1 [1.9 to 2.2] for total; 1.9 [1.8 to 2.0] for direct; 2.0 [1.9 to 2.2] for indirect bilirubin). Conclusions: In this study, bilirubin subtypes are inversely associated with smoking status, smoking amount, and smoking duration in healthy Korean men independently of hemoglobin. Further studies are needed to investigate this association in healthy Korean women.

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참고문헌

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  2. Smoking Cessation Is Followed by Increases in Serum Bilirubin, an Endogenous Antioxidant Associated With Lower Risk of Lung Cancer and Cardiovascular Disease vol.16, pp.8, 2012, https://doi.org/10.1093/ntr/ntu067
  3. The Relationship between Total Bilirubin Levels and Total Mortality in Older Adults: The United States National Health and Nutrition Examination Survey (NHANES) 1999-2004 vol.9, pp.4, 2012, https://doi.org/10.1371/journal.pone.0094479
  4. Combined Effects of Smoking and Bilirubin Levels on the Risk of Lung Cancer in Korea: The Severance Cohort Study vol.9, pp.8, 2014, https://doi.org/10.1371/journal.pone.0103972
  5. Serum bilirubin concentration is modified by UGT1A1 Haplotypes and influences risk of Type-2 diabetes in the Norfolk Island genetic isolate vol.16, pp.None, 2015, https://doi.org/10.1186/s12863-015-0291-z
  6. Cigarette Smoking Habit and Subjective Quality of Sleep vol.3, pp.1, 2015, https://doi.org/10.5812/scimetr.18454
  7. Active and Passive Smoking and Serum Total Bilirubin in a Rural Korean Population vol.18, pp.5, 2012, https://doi.org/10.1093/ntr/ntv251
  8. Cigarette smoking behaviour and blood metabolomics vol.45, pp.5, 2012, https://doi.org/10.1093/ije/dyv330
  9. Direct Bilirubin Levels and Risk of Metabolic Syndrome in Healthy Chinese Men vol.2017, pp.None, 2012, https://doi.org/10.1155/2017/9621615
  10. Association between elevated serum bilirubin levels with preserved lung function under conditions of exposure to air pollution vol.21, pp.1, 2012, https://doi.org/10.1186/s12890-021-01488-5