Journal of the Korean Society of Physical Medicine (대한물리의학회지)

The Korean Society of Physical Medicine (대한물리의학회)
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Effects of Repetitive Transcranial Magnetic Stimulation on Enhancement of Cognitive Function in Focal Ischemic Stroke Rat Model

국소 허혈성 뇌졸중 모델 흰쥐의 인지기능에 반복경두개자기자극이 미치는 효과

  • Lee, Jung-In (Department of Physical Therapy, Dongshin University Oriental Hospital) ;
  • Kim, Gye-Yeop (Department of Physical Therapy, Dongshin University) ;
  • Nam, Ki-Won (Department of Physical Therapy, Dongshin University) ;
  • Lee, Dong-Woo (Department of Physical Therapy, Gwangju Jungang Hospital) ;
  • Kim, Ki-Do (Department of Physical therapy, Korea International University) ;
  • Kim, Kyung-Yoon (Department of Physical Therapy, Dongshin University)
  • 이정인 (동신대 목포한방병원 물리치료실) ;
  • 김계엽 (동신대학교 물리치료학과) ;
  • 남기원 (동신대학교 물리치료학과) ;
  • 이동우 (광주중앙병원 물리치료실) ;
  • 김기도 (한국국제대학교 물리치료학과) ;
  • 김경윤 (동신대학교 물리치료학과)
  • Received : 2012.01.21
  • Accepted : 2012.02.20
  • Published : 2012.02.29
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Abstract

Purpose : This study is intended to examine the repetitive transcranial magnetic stimulation on cognitive function in the focal ischemic stroke rat model. Methods : This study selected 30 Sprague-Dawley rats of 8 weeks. The groups were divided into two groups and assigned 15 rats to each group. Control group: Non-treatment after injured by focal ischemic stroke; Experimental group: application of repetitive transcranial magnetic stimulation(0.1 Tesla, 25 Hz, 20 min/time, 2 times/day, 5 days/2 week) after injured by focal ischemic stroke. To assess the effect of rTMS, the passive avoidance test, spatial learning and memory ability test were analyzed at the pre, 1 day, $7^{th}$ day, $14^{th}$ day and immunohistochemistric response of BDNF were analyzed in the hippocampal dentate gyrus at $7^{th}$ day, $14^{th}$ day. Results : In passive avoidance test, the outcome of experimental group was different significantly than the control group at the $7^{th}$ day, $14^{th}$ day. In spatial learning and memory ability test, the outcome of experimental group was different significantly than the control group at the $7^{th}$ day, $14^{th}$ day. In immunohistochemistric response of BDNF in the hippocampal dentate gyrus, experimental groups was more increased than control group. Conclusion : These result suggest that improved cognitive function by repetitive transcranial magnetic stimulation after focal ischemic stroke is associated with dynamically altered expression of BDNF in hippocampal dentate gyrus and that is related with synaptic plasticity.

Keywords

References

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