Asian Pacific Journal of Cancer Prevention

  • 제13권1호
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  • Pages.399-402
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  • 2012
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  • 1513-7368(pISSN)
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  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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Bufalin, a Traditional Oriental Medicine, Induces Apoptosis in Human Cancer Cells

  • Takai, Noriyuki (Department of Obstetrics and Gynecology, Oita University Faculty of Medicine) ;
  • Kira, Naoko (Department of Obstetrics and Gynecology, Oita University Faculty of Medicine) ;
  • Ishii, Terukazu (Department of Obstetrics and Gynecology, Oita University Faculty of Medicine) ;
  • Yoshida, Toshie (Department of Obstetrics and Gynecology, Oita University Faculty of Medicine) ;
  • Nishida, Masakazu (Department of Obstetrics and Gynecology, Oita University Faculty of Medicine) ;
  • Nishida, Yoshihiro (Department of Obstetrics and Gynecology, Oita University Faculty of Medicine) ;
  • Nasu, Kaei (Department of Obstetrics and Gynecology, Oita University Faculty of Medicine) ;
  • Narahara, Hisashi (Department of Obstetrics and Gynecology, Oita University Faculty of Medicine)
  • 발행 : 2012.01.31
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초록

Bufalin is a traditional oriental medicines which induces apoptosis in some lines of human tumor cells. It constitutes the major digoxin-like immunoreactive component of Chan Su, obtained from the skin and parotid venom glands of toads. Bufalin is cardioactive C-24 steroids that exhibits a variety of biological activities, such as cardiotonic, anaesthetic, blood pressure stimulatory, respiratory and antineoplastic effects. In terms of its anti-tumor activity, bufalin has been demonstrated to inhibit the growth of tumors, such as endometrial and ovarian cancers. This commentary introduces biologic and therapeutic effects of bufalin in treating some cancers. The compound is able to mediate inhibition of cell growth, cell cycle arrest, apoptosis, and expression of genes related to the malignant phenotype in human cancer cells.

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참고문헌

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피인용 문헌

  1. Cytotoxicity, Apoptosis Induction and Anti-Metastatic Potential of Oroxylum indicum in Human Breast Cancer Cells vol.13, pp.6, 2012, https://doi.org/10.7314/APJCP.2012.13.6.2729
  2. AKT serine/threonine protein kinase modulates bufalin-triggered intrinsic pathway of apoptosis in CAL 27 human oral cancer cells vol.41, pp.5, 2012, https://doi.org/10.3892/ijo.2012.1605
  3. Bufalin prevents the migration and invasion of T24 bladder carcinoma cells through the inactivation of matrix metalloproteinases and modulation of tight junctions vol.42, pp.1, 2013, https://doi.org/10.3892/ijo.2012.1683
  4. Anticancer Effects of Bufalin on Human Hepatocellular Carcinoma HepG2 Cells: Roles of Apoptosis and Autophagy vol.14, pp.1, 2013, https://doi.org/10.3390/ijms14011370
  5. Bufalin induces G2/M phase arrest and triggers autophagy via the TNF, JNK, BECN-1 and ATG8 pathway in human hepatoma cells vol.43, pp.1, 2013, https://doi.org/10.3892/ijo.2013.1942
  6. Targeting Poly (ADP-Ribose) Polymerase Partially Contributes to Bufalin-Induced Cell Death in Multiple Myeloma Cells vol.8, pp.6, 2013, https://doi.org/10.1371/journal.pone.0066130
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  8. Blocking autophagy enhances the apoptosis effect of bufalin on human hepatocellular carcinoma cells through endoplasmic reticulum stress and JNK activation vol.19, pp.1, 2014, https://doi.org/10.1007/s10495-013-0914-7
  9. Bufalin Alters Gene Expressions Associated DNA Damage, Cell Cycle, and Apoptosis in Human Lung Cancer NCI-H460 Cells in Vitro vol.19, pp.5, 2014, https://doi.org/10.3390/molecules19056047
  10. Bufalin Exerts Inhibitory Effects on IL-1β-Mediated Proliferation and Induces Apoptosis in Human Rheumatoid Arthritis Fibroblast-Like Synoviocytes vol.37, pp.5, 2014, https://doi.org/10.1007/s10753-014-9882-5
  11. Resibufogenin and Cinobufagin Activate Central Neurons through an Ouabain-Like Action vol.9, pp.11, 2014, https://doi.org/10.1371/journal.pone.0113272
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  13. An in silico Appraisal to Identify High Affinity Anti-Apoptotic Synthetic Tetrapeptide Inhibitors Targeting the Mammalian Caspase 3 Enzyme vol.15, pp.23, 2014, https://doi.org/10.7314/APJCP.2014.15.23.10137
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