Asian Pacific Journal of Cancer Prevention

  • 제13권1호
  • /
  • Pages.325-328
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  • 2012
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  • 1513-7368(pISSN)
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  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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Lack of Association Between GSTM1 and GSTT1 Polymorphisms and Brain Tumour Risk

  • Sima, Xiu-Tian (Department of Neurosurgery, West China Hospital of Sichuan University) ;
  • Zhong, Wei-Ying (Department of Neurosurgery, West China Hospital of Sichuan University) ;
  • Liu, Jian-Gang (Department of Neurosurgery, Shenzhen Children Hospital) ;
  • You, Chao (Department of Neurosurgery, West China Hospital of Sichuan University)
  • 발행 : 2012.01.31
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초록

Objective: Glutathione S-transferases (GSTs) are important enzymes that are involved in detoxification of environmental carcinogens. Molecular epidemiological studies have been conducted to investigate the association between GSTM1 and GSTT1 homozygous deletion polymorphisms and brain tumours but results have been conflicting. The aim of this study was to clarify this problem using a meta-analysis. Methods: A total of 9 records were identified by searching the PubMed and Embase databases. Fixed- and random-effects models were performed to estimate the pooled odds ratios. Results: No significant association was found between the GSTM1 and GSTT1 homozygous deletion polymorphisms and risk of brain tumours, including glioma and meningioma. Similar negative results were also observed in both population-based and hospital-based studies. Conclusion: These findings indicate that the GSTM1 and GSTT1 polymorphisms may not be related to the development of brain tumours.

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참고문헌

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피인용 문헌

  1. Meta-analysis of GSTM1 and GSTT1 Polymorphisms and Risk of Nasopharyngeal Cancer vol.14, pp.3, 2013, https://doi.org/10.7314/APJCP.2013.14.3.1697
  2. Investigation of the Association between Genetic Polymorphism of Microsomal Epoxide Hydrolase and Primary Brain Tumor Incidence vol.2013, pp.2090-2190, 2013, https://doi.org/10.1155/2013/189237
  3. Associations between the rs6010620 Polymorphism in RTEL1 and Risk of Glioma: a Meta-analysis of 20,711 Participants vol.15, pp.17, 2014, https://doi.org/10.7314/APJCP.2014.15.17.7163
  4. Genetic Contribution of Polymorphisms in Glutathione S-Transferases to Brain Tumor Risk vol.53, pp.3, 2016, https://doi.org/10.1007/s12035-015-9097-2