Preventive Nutrition and Food Science

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Effect of Persimmon Leaf Extract on Phthalic Anhydride-induced Allergic Response in Mice

  • Mok, Ji-Ye (Jeonju University Atopy & Health Research Institute) ;
  • Jeon, In-Hwa (School of Alternative Medicine & Health Science, College of Alternative Medicine, Jeonju University) ;
  • Cho, Jung-Keun (Department of Radiological Science, College of Alternative Medicine, Jeonju University) ;
  • Park, Ji-Min (School of Alternative Medicine & Health Science, College of Alternative Medicine, Jeonju University) ;
  • Kim, Hyeon-Soo (School of Alternative Medicine & Health Science, College of Alternative Medicine, Jeonju University) ;
  • Kang, Hyun-Ju (School of Alternative Medicine & Health Science, College of Alternative Medicine, Jeonju University) ;
  • Kim, Hyung-Soon (Moakgol Association) ;
  • Jang, Seon-Il (Jeonju University Atopy & Health Research Institute)
  • Received : 2012.01.18
  • Accepted : 2012.03.07
  • Published : 2012.03.31
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Abstract

The purpose of this study was to investigate the anti-allergy activities of persimmon leaf extract (PLE) on a phthalic anhydride (PA)-induced allergic mouse model. A human leukemic mast cell line (HMC-1) was used to examine the inhibitory activity of PLE on the histamine release by human leukemic mast cells. PLE inhibited histamine release from HMC-1 cells in response to cross-linkage of high-affinity IgE receptor-${\alpha}$ ($Fc{\varepsilon}RI{\alpha}$). Additionally, a PA-induced allergic mouse model was used to investigate the effects of PLE in vivo. Mice were orally administrated with or without PLE of single dose (250 mg/kg/day) for 31 days. Oral intake of PLE significantly inhibited passive cutaneous reactions. Oral administration of PLE to PA-induced allergic mice also led to a striking suppression of the development of contact dermatitis, ear swelling and lymph node weight. In addition, PA-specific IL-4 production of draining lymph node cells was markedly diminished by PLE oral administration, but not IFN-${\gamma}$. Furthermore, PLE treatment suppressed PA-induced thymus and activation-regulated chemokine (CCL17) and cutaneous T cell-attracting chemokine (CCL27) expressions in ear tissues. Based on these results, we suggest that PLE may have therapeutic potential as an effective material for management of irritant contact dermatitis or related inflammatory diseases.

Keywords

References

  1. Ban M, Hettich D. 2005. Effect of Th2 cytokine antagonist treatments on chemical-induced allergic response in mice. J Appl Toxicol 25: 239-247. https://doi.org/10.1002/jat.1062
  2. Kay AB. 2001. Allergy and allergic diseases. First of two parts. N Engl J Med 344: 30-37. https://doi.org/10.1056/NEJM200101043440106
  3. Incorvaia C, Frati F, Verna N, D'Alo S, Motolese A, Pucci S. 2008. Allergy and the skin. Clin Exp Immunol 153 (Suppl 1): 27-29. https://doi.org/10.1111/j.1365-2249.2008.03718.x
  4. Hirota R, Roger NN, Nakamura H, Song HS, Sawamura M, Suganuma N. 2010. Anti-inflammatory effects of limonene from yuzu (Citrus junos Tanaka) essential oil on eosinophils. J Food Sci 75: H87-92. https://doi.org/10.1111/j.1750-3841.2010.01541.x
  5. Zhang Y, Lamm WJ, Albert RK, Chi EY, Henderson WR Jr, Lewis DB. 1997. Influence of the route of allergen administration and genetic background on the murine allergic pulmonary response. Am J Respir Crit Care Med 155: 661-669. https://doi.org/10.1164/ajrccm.155.2.9032210
  6. Dubois GR, Bruijnzeel PL. 1994. IL-4-induced migration of eosinophils in allergic inflammation. Ann N Y Acad Sci 725: 268-273. https://doi.org/10.1111/j.1749-6632.1994.tb39809.x
  7. Nomura I, Goleva E, Howell MD, Hamid QA, Ong PY, Hall CF, Darst MA, Gao B, Boguniewicz M, Travers JB, Leung DY. 2003. Cytokine milieu of atopic dermatitis, as compared to psoriasis, skin prevents induction of innate immune response genes. J Immunol 171: 3262-3269. https://doi.org/10.4049/jimmunol.171.6.3262
  8. Boguniewicz M. 2004. Update on atopic dermatitis: insights into pathogenesis and new treatment paradigms. Allergy Asthma Proc 25: 279-282.
  9. Kurahashi R, Hatano Y, Katagiri K. 2008. IL-4 suppresses the recovery of cutaneous permeability barrier functions in vivo. J Invest Dermatol 128: 1329-1331. https://doi.org/10.1038/sj.jid.5701138
  10. Leung DY, Boguniewicz M, Howell MD, Nomura I, Hamid QA. 2004. New insights into atopic dermatitis. J Clin Invest 113: 651-657. https://doi.org/10.1172/JCI21060
  11. Sebastiani S, Denelon G, Gerber B, Uguccioni M. 2005. CCL22 induced responses are powerfully enhanced by synergy inducing chemokines via CCR4: evidence for the involvement of b strand of chemokine. Eur J Immunol 35: 746-756. https://doi.org/10.1002/eji.200525800
  12. Nakazato J, Kishida M, Kuroiwa R, Fujiwara J, Shimoda M, Shinomiya N. 2008. Serum levels of Th2 chemokines, CCL17, CCL22, and CCL27, were the important markers of severity in infantile atopic dermatitis. Pediatr Allergy Immunol 19: 605-613.
  13. Han J, Kang S, Choue R, Kim H, Leem K, Chung S, Kim C, Chung J. 2002. Free radical scavenging effect of Diospyros kaki, Laminaria japonica and Undaria pinnatifida. Fitoterapia 73: 710-712. https://doi.org/10.1016/S0367-326X(02)00236-8
  14. Bei WJ, Xu AL, Li CY, Cabot PJ, Hermanussen S. 2009. Flavonoids from Diospyros kaki inhibit the adhesion between lymphocyte and dorsal root ganglion. Zhong Yao Cai 32: 740-744.
  15. Cho JK, Jeon IH, Park JM, Kim HS, Jang SI. 2011. Inhibitory effect of persimmon leaf extract on development of atopic dermatitis-like skin lesions. J Korean Soc Appl Biol Chem 54: 653-657. https://doi.org/10.3839/jksabc.2011.100
  16. Matsuda H, Watanabe N, Geba GP, Sperl J, Tsudzuki M, Hiroi J, Matsumoto M, Ushio H, Saito S, Askenase PW, Ra C. 1997. Development of atopic dermatitis-like skin lesion with IgE hyperproduction in NC/Nga mice. Int Immunol 9: 461-466. https://doi.org/10.1093/intimm/9.3.461
  17. Gober MD, Gaspari AA. 2008. Allergic contact dermatitis. Curr Dir Autoimmun 10: 21-26.
  18. Queralt M, Brazís P, Merlos M, de Mora F, Puigdemont A. 2000. In vitro inhibitory effect of rupatadine on histamine and TNF-alpha release from dispersed canine skin mast cells and the human mast cell line HMC-1. Inflamm Res 49: 355-360. https://doi.org/10.1007/PL00000216
  19. Kotani M, Matsumoto M, Fujita A, Higa S, Wang W, Suemura M, Kishimoto T, Tanaka T. 2000. Persimmon leaf extract and astragalin inhibit development of dermatitis and IgE elevation in NC/Nga mice. J Allergy Clin Immun 106: 159-166. https://doi.org/10.1067/mai.2000.107194
  20. Gao XK, Nakamura N, Fuseda K, Tanaka H, Inagaki N, Nagai H. 2004. Establishment of allergic dermatitis in NC/ Nga mice as a model for severe atopic dermatitis. Biol Pharm Bull 27: 1376-1381. https://doi.org/10.1248/bpb.27.1376
  21. Dearman RJ, Skinner RA, Humphreys NE, Kimber I. 2003. Methods for the identification of chemical respiratory allergens in rodents: comparisons of cytokine profiling with induced changes in serum IgE. J Appl Toxicol 23: 199-207. https://doi.org/10.1002/jat.907
  22. Stahlmann R, Wegner M, Riecke K, Kruse M, Platzek T. 2006. Sensitising potential of four textile dyes and some of their metabolites in a modified local lymph node assay. Toxicology 219: 113-123. https://doi.org/10.1016/j.tox.2005.11.005
  23. Goleva E, Dunlap A, Leung DY. 2004. Differential control of Th1 versus Th2 cell responses by the combination of low-dose steroids with beta2-adrenergic agonists. J Allergy Clin Immun 114: 183-191. https://doi.org/10.1016/j.jaci.2004.04.001
  24. Umetsu DT, DeKruyff RH. 2006. The regulation of allergy and asthma. Immunol Rev 212: 238-255. https://doi.org/10.1111/j.0105-2896.2006.00413.x
  25. Ohtani T, Nakagawa S, Kurosawa M, Mizuashi M, Ozawa M, Aiba S. 2005. Cellular basis of the role of diesel exhaust particles in inducing Th2-dominant response. J Immunol 174: 2412-2419. https://doi.org/10.4049/jimmunol.174.4.2412
  26. Vestergaard C, Yoneyama H, Murai M, Nakamura K, Tamaki K, Terashima Y, Imai T, Yoshie O, Irimura T, Mizutani H, Matsushima K. 1999. Overproduction of Th2-specific chemokines in NC/Nga mic exhibiting atopic dermatitis-like lesions. J Clin Invest 104: 1097-1105. https://doi.org/10.1172/JCI7613
  27. Homey B, Alenius H, Müller A, Soto H, Bowman EP, Yuan W, McEvoy L, Lauerma AI, Assmann T, Bünemann E, Lehto M, Wolff H, Yen D, Marxhausen H, To W, Sedgwick J, Ruzicka T, Lehmann P, Zlotnik A. 2002. CCL27-CCR10 interactions regulate T cell-mediated skin inflammation. Nat Med 8: 157-165. https://doi.org/10.1038/nm0202-157
  28. Kawakami K, Aketa S, Nakanami M, Iizuka S, Hirayama M. 2010. Major water-soluble polyphenols, proanthocyanidins, in leaves of persimmon (Diospyros kaki) and their alpha-amylase inhibitory activity. Biosci Biotechnol Biochem 74: 1380-1385. https://doi.org/10.1271/bbb.100056
  29. Chen G, Wei SH, Huang J, Sun J. 2009. A novel C-glycosylflavone from the leaves of Diospyros kaki. J Asian Nat Prod Res 11: 503-507. https://doi.org/10.1080/10286020902911512

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