Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
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Effects of Tested Pack Containing Plant Extracts on Elasticity and Size of Women's Breasts

식물추출물 팩의 여성가슴 탄력증진과 크기증대에 관한 연구

  • Choi, Yea-Hun (Department of Life Science & Environmental Biochemistry, Pusan National University) ;
  • Park, Min-Kyung (Department of Life Science & Environmental Biochemistry, Pusan National University) ;
  • Kim, Yong-Gyun (Department of Life Science & Environmental Biochemistry, Pusan National University) ;
  • Lee, Sang-Mong (Department of Life Science & Environmental Biochemistry, Pusan National University) ;
  • Son, Hong-Joo (Department of Life Science & Environmental Biochemistry, Pusan National University) ;
  • Park, Hyean-Cheal (Department of Life Science & Environmental Biochemistry, Pusan National University) ;
  • Kim, Sun-Tae (Department of Plant Bioscience, Pusan National University) ;
  • Choi, In-Soo (Department of Plant Bioscience, Pusan National University) ;
  • Kim, Keun-Ki (Department of Life Science & Environmental Biochemistry, Pusan National University)
  • 최예훈 (부산대학교 생명환경화학과) ;
  • 박민경 (부산대학교 생명환경화학과) ;
  • 김용균 (부산대학교 생명환경화학과) ;
  • 이상몽 (부산대학교 생명환경화학과) ;
  • 손홍주 (부산대학교 생명환경화학과) ;
  • 박현철 (부산대학교 생명환경화학과) ;
  • 김선태 (부산대학교 식물생명과학과) ;
  • 최인수 (부산대학교 식물생명과학과) ;
  • 김근기 (부산대학교 생명환경화학과)
  • Received : 2012.02.15
  • Accepted : 2012.03.14
  • Published : 2012.03.30
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Abstract

In this study, we purified the extracts from the seeds and the roots of various plant species, including Q. acutissima, C. lanceolata, P. mirifica, P. bambusoides, and S. repens, and then investigated the effects of these extracts on cell growth and fat accumulation in adipocytes. We found that the extracts purified from Q. acutissima, C. lanceolata, P. mirifica, P. bambusoides, and S. repens more effectively increased the cell growth, as well as promoting the fat accumulation in adipocytes to a greater extent, than other extracts in vitro. Therefore, we made breast packs containing these effective extracts, and then investigated whether they were effective in enhancing the elasticity and volume of women's breasts. The measurements of breast elasticity and size revealed that the breast packs efficiently increased the elasticity and size of women's breasts. Furthermore, evaluation of the questionnaires related to usage of the breast packs indicated great satisfaction in terms of the lift, firmness, and elasticity of breasts. In conclusion, extracts purified from Q. acutissima, C. lanceolata, P. mirifica, P. bambusoides, and S. repens leading to cell growth and fat accumulation in adipocytes can effectively contribute to improving the elasticity and size of women's breasts.

본 연구는 콩과식물과 허브식물 및 국내 자생식물체들로부터 estrogen 생성과 대사에 활성을 나타내는 물질을 발굴하기 위하여, 12종의 식물체로부터 식물 유래의 isoflavone류를 포함한 2차대사산물을 용매로 추출하여 지방세포의 지방합성과 축적에 활성을 조사하였다. 활성을 보이는 Q. acutissima, C. lanceolata, P. mirifica, P. bambusoides 및 S. repens 5종의 식물체 용매추출물을 전체중량의 3% 되게 첨가하여 천연 팩을 제조하였으며 임상실험을 통하여 가슴의 탄력과 크기변화에 미치는 영향을 조사하였다. C. lanceolata 추출물을 $25{\mu}g/ml$ 농도로 처리한 곳에서 3T3-L1의 세포성장을 control과 비교했을 때 130% 이상 증가시켰으며, 지방의 축적은 S. repens $H_2O$ 추출물을 처리한 곳에서 190% 정도 지방축적량이 많았으며, C. lanceolata와 P. bambusoides EtOH 추출물을 처리한 곳에서도 각각 145%와 154% 활성이 높게 나타났다. 지방합성을 촉진하는 식물체추출물들을 첨가하여 천연 팩을 제조하였으며, 제조한 팩으로 더마프로에 가슴크기 변화와 탄력에 미치는 영향 등의 임상실험을 의뢰하였다. 임상 실험 결과, 가슴둘레, 탄력, 볼륨이 모두 유의적으로 향상되는 것을 확인할 수 있었고. 효능에 관한 설문평가 결과, 사용효과 항목에서 80% 이상의 긍정적으로 답하였으며, 사용 후 2주간 효과에 대해 65%이상이 긍정적인 응답을 하였다. 사용성 설문평가 결과 또한 피험자의 90%이상이 긍정적으로 평가하였다. 피부 안전성 평가에서는 피험자 6명이 사용 중 가려움을 호소하였으나, 그 증상이 미약하여 사용에는 문제가 없었으며, 1명은 사용 3일 후 홍반이 관찰되었으나 5일 후 소멸되었고, 그 외의 다른 이상반응은 관찰되지 않아 인체에 대한 부작용의 문제는 없었다. 이상의 연구 결과, Q. acutissima, C. lanceolata, P. mirifica, P. bambusoides 및 S. repens의 추출물을 혼합하여 첨가한 겔타입의 팩 제조물은 여성의 가슴크기 향상과 탄력유지에 유효하다는 사실을 세포수준의 실험과 임상실험에서 그 효과를 확인 할 수 있었다.

Keywords

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