Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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The Safety Evaluation of a Potent Angiogenic Activator, Synthetic Peptide (SFKLRY-NH2) for the Skin Application

  • Kim, Dong-Ha (Department of Dermatology, Chung-Ang University College of Medicine) ;
  • Lim, Yun-Young (Department of Dermatology, Chung-Ang University College of Medicine) ;
  • Kim, Hyeong-Mi (Department of Dermatology, Chung-Ang University College of Medicine) ;
  • Kim, So-Young (Department of Dermatology, Chung-Ang University College of Medicine) ;
  • Kim, Beom-Joon (Department of Dermatology, Chung-Ang University College of Medicine) ;
  • Park, Sung-Gil (NOVACELL Technology) ;
  • Lee, Tae-Hoon (NOVACELL Technology) ;
  • Cho, Soo-Muk (Functional Food & Nutrition Division, National Academy of Agricultural Science, Rural Development Administration)
  • Received : 2011.11.19
  • Accepted : 2012.03.29
  • Published : 2012.03.31
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Abstract

A novel synthetic hexapeptide (SFKLRY-$NH_2$) that displays angiogenic activity has been identified by positional scanning of a synthetic peptide combinatorial library (PS-SPCL). This study was carried out to investigate the irritation of the SFKLRY-$NH_2$ on the skin. The tests were performed on the basis of Korea Food and Drug Administration (KFDA) guidelines. In results, cell toxicity is not appeared for SFKLRY-$NH_2$ in HaCaT cells and B16F10 cells. SFKLRY-$NH_2$ induced no skin irritation at low concentration ($10{\mu}m$), mild irritation at high concentration (10mM). We consider that this result is helpful for saying about the safety of SFKLRY-$NH_2$ in clinical use.

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