Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Chemical Constituents from the Bark of Phellodendron amurense and Their Cytotoxic Effects on HL-60 Human Leukemia Cells

  • Li, Wei (College of Pharmacy, Chungnam National University) ;
  • Sun, Ya Nan (College of Pharmacy, Chungnam National University) ;
  • Yan, Xi Tao (College of Pharmacy, Chungnam National University) ;
  • Yang, Seo Young (College of Pharmacy, Chungnam National University) ;
  • Choi, Chun Whan (College of Pharmacy, Chungnam National University) ;
  • Kim, Eun Ji (School of Medicine and Institute of Medical Science, Jeju National University) ;
  • Kang, Hee Kyoung (School of Medicine and Institute of Medical Science, Jeju National University) ;
  • Kim, Young Ho (College of Pharmacy, Chungnam National University)
  • Received : 2012.09.02
  • Accepted : 2012.11.09
  • Published : 2012.12.31
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Abstract

Phellodendri Cortex, phellodendron bark, has been used as a stomachic for intestinal function control and as an antimicro and anti-inflammatory agent. In this phytochemical study, eight compounds, berberine (1), palmatine (2), syringin (3), (+)-syringaresinol di-O-${\beta}$-D-glucopyranoside (4), salvadoraside (5), citrusin B (6), osmanthuside H (7), and kelampayoside A (8), were isolated from the bark of Phellodendron amurense. Their structures were elucidated by comparing spectroscopic data with reported values. Compounds 1 - 8 were evaluated for cytotoxic activity against HL-60 human promyelocytic leukemia cells in vitro. Among them, compounds 1 and 2 reduced the viability of HL-60 cells significantly, with $IC_{50}$ values of 26.0 and $18.5{\mu}M$, respectively.

Keywords

References

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