Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Sedative and Antinociceptive Properties of Lindera obtusiloba

  • Lee, Yong Jae (College of Pharmacy, Woosuk University) ;
  • Lee, Dong Keon (College of Pharmacy, Woosuk University) ;
  • Kim, Jong Soo (College of Pharmacy, Woosuk University) ;
  • Park, Kyoung Jae (College of Pharmacy, Woosuk University) ;
  • Cha, Dong Seok (College of Pharmacy, Woosuk University) ;
  • Kim, Dae Keun (College of Pharmacy, Woosuk University) ;
  • Kwon, Jin (Department of Prosthetics and Orthotics, Korea National College of Rehabilitation and Welfare) ;
  • Oh, Chan Ho (Department of Biotechnology, Graduate School, Woosuk University) ;
  • Kim, Kang San (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Jeon, Hoon (College of Pharmacy, Woosuk University)
  • Received : 2012.08.27
  • Accepted : 2012.10.24
  • Published : 2012.12.31
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Abstract

The stem of Lindera obtusiloba (Lauraceae), has been widely used as a traditional medicine for the treatment of abdominal pain, bruise and hepatocirrhosis. In the present study, antinociceptive and sedative properties of the methanol extract of L. obtusiloba (MLO) were evaluated. MLO demonstrated strong and dose-dependent antinociceptive activities on various experimental pain models including thermal nociception and chemical nociception, compared to tramadol and indomethacin, reference drugs. In combination test using naloxone, the diminished analgesic activity of MLO was observed, indicating the relation with opioid receptor. Moreover, MLO also decreases pentobarbital-induced sleep latency and increases sleeping time suggesting its hypnotic and sedative action. The present results indicate that MLO could be used as valuable antinociceptive and sedative agent for the treatment of various diseases.

Keywords

References

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