DOI QR코드

DOI QR Code

Preventive effects of Saponariae Vaccariae Semen and Melandryi Firmi Herba on hyperlipidemia and liver damage induced by alcohol

왕부류행(王不留行)과 경엽여루채(硬葉女婁菜)가 알콜 투여로 유발된 흰쥐의 고지혈증과 간 손상의 예방에 미치는 영향

  • Choi, Jae-Young (Department of Oriental Medicine, Daegu Haany University) ;
  • Seo, Bu-Il (Department of Oriental Medicine, Daegu Haany University) ;
  • Oh, Dal-Seok (Korea Institute of Oriental Medicine) ;
  • Park, Ji-Ha (Department of Oriental Medicine, Daegu Haany University) ;
  • Roh, Seong-Soo (Department of Oriental Medicine, Daegu Haany University)
  • 최재영 (대구한의대학교 한의과대학 본초학교실) ;
  • 서부일 (대구한의대학교 한의과대학 본초학교실) ;
  • 오달석 (한국한의학연구원) ;
  • 박지하 (대구한의대학교 한의과대학 본초학교실) ;
  • 노성수 (대구한의대학교 한의과대학 본초학교실)
  • Received : 2011.11.19
  • Accepted : 2012.01.13
  • Published : 2012.01.30

Abstract

Objectives : This study was performed to compare the preventive effect of water extracts from Saponariae Vaccariae Semen(SVS) and Melandryi Firmi Herba(MFH) on hyperlipidemia and liver damage induced by alcohol. Methods : Except for the normal group, I fed rat on 25% alcohol for 55 days. And each extract was administrated for the same period. I measured the serum component in rat's blood, body weight and weight of liver. Results : At first, I observed effects of SVS and MFH on hyperlipidemia induced by alcohol. SVS and MFH group didn't show the significant decrease of total cholesterol in comparison with those of the control group. SVS and MFH group showed the significant increase of HDL-cholesterol in comparison with those of the control group. SVS group showed the significant decrease of triglyceride in comparison with those of the control group, but MFH group didn't show the significant decrease of triglyceride in comparison with those of the control group. SVS group showed the significant increase of body weight in comparison with those of the control group at 4weeks and 8weeks. But, MFH group didn't show the significant changes of body weight in comparison with those of the control group at 4weeks and 8weeks. By the way, SVS group showed the significant decrease of triglyceride in comparison with those of MFH group. SVS group showed the significant increase of body weight in comparison with those of MFH group at 8weeks. At second, I observed effects of SVS and MFH on liver damage induced by alcohol. SVS and MFH group showed the significant decrease of AST(aspartate aminotransferase), ALT(alanine aminotransferase), ALP(alkaline phosphatase) and LDH(lactate dehydrogenase) in comparison with those of the control group. SVS group showed the significant increase of liver weight in comparison with those of the control group, but MFH group didn't show the significant increase of liver weight in comparison with those of the control group. By the way, SVS group showed the significant increase of liver weight in comparison with those of MFH group. Conclusions : Reviewing these experimental results, it suggests that water extracts from SVS and MFH have pharmaceutical preventive efficacy on hyperlipidemia and liver damage induced by alcohol. Therefore further additional study should be conducted to elucidate the pharmaceutical efficacy of these in depth.

Keywords

References

  1. Department of herbal standard, KFDA. The Korean herbal pharmacopoeia. Seoul:KFDA. 2007:258.
  2. Guojiayaodianweiyuanhui. Zhonghuarenmingongheguoyaodian. Beijing: Huaxuegongye publisher. 2000:40.
  3. Guojiazhongyiyaoguanliju Zhonghuabencaobianweihui. Zhonghuabencao(2 volume). Shanghai:Shanghaikexuejishu publisher. 1999:787-788, 790-791.
  4. Lee JG. 2008 Statistics on national heath(4th investigation on national heath and nutrition) (2008). Seoul:Korea Centers for Disease Control and Prevention. 2009:91-98.
  5. Jeong EM. Analysis of death rate in the patients of liver cirrhosis. Statistics Korea. 2001 Korean social index. 2002:294-7, 300-3.
  6. Jeong EM, Hwang SG, Park HH, Park JH, Kim HT, Oh SW, et al. The Anaylsis of Mortality Rate According to CTP Score and MELD Score in Patients with Liver Cirrhosis. The Korean Journal of Hepatology. 2003;9(2):98-106.
  7. Wang Z, Yao T, Song Z. Chronic alcohol consumption disrupted cholesterol homeostasis in rats:down-regulation of low-density lipoprotein receptor and enhancement of cholesterol biosynthesis pathway in the liver. Alcohol Clin Exp Res. 2010 Mar 1;34(3):471-8. Epub 2009 Dec 18. https://doi.org/10.1111/j.1530-0277.2009.01111.x
  8. Park SM, Cho CK. The study of oriental medicine and western medicine on the effect of acohol. The Journal of Research Institute of Korean Medicine at Daejeon University. 1993;2(1):67-78.
  9. Liu, S.J., Ramsey, R.K. and Fallon, H.J. Effects of ethanol on hepatic microsomaldrug-metabolizing enzymes in the rat. Biochem. Pharmacol. 1975;24:369-378. https://doi.org/10.1016/0006-2952(75)90220-8
  10. Kanai Izmi, The editorial department of Komoonsa. The manual about clinical tests. Seoul:Komoonsa. 1993:432-442, 449-452, 472-480, 489-503.
  11. Yanzhenghua. Zhongyaoxue. Beijing: Renminweisheng publisher. 1991:575-576.
  12. Kim HK, Lee HW, Hwang SW, Ko BS. Quantitative Analysis of 20-hydroxyecdysone in Melandrii Herba. Kor. J. Pharmacognosy. 2002;33(2):96-99.
  13. Lim SH. Flavonoid constituents of Melandryum firmum Rohrbach. Graduate School of Sunmoon University. 2000.
  14. Woo EH. Chemical structure of melandriosides from Melandrium firmum. Graduate School of Seoul University. 1994.
  15. Woo EH, Woo WS. Studies on the constituents of Melandrium Firmum Rohrb(I). Kor. J. Pharmacognosy. 1989;20(1):56.
  16. Woo EH, Woo WS. Studies on the constituents of Melandrium Firmum Rohrb(II). Kor. J. Pharmacognosy. 1989;20(1):56.
  17. Woo WS, Chang HS and Choi JS. Phytochemical study on Melandrium firmum(4). Kor. J. Pharmacognosy. 1987;18(1):68-69.
  18. The textbook compilation committee of korean herbology. Korean herbology. 4th revised edition. Seoul:Younglimsa. 1998:436-437.
  19. Man-Hee Lee, Hyo-Sang Han, Young-Jong Lee. Comparative Studies on the Hyperlipidemia of Melandrii Herba and Vaccariae Semen. Kor. J. Herbology. 2010;25(3):81-90.
  20. Eun Young Jung, Ji Ha Park, Bu Il Seo. The effects of Saponariae Vaccariae Semen and Melandryi Firmi Herba extracts on hydrocortisone acetate-induced model of blood stasis. The Journal of Applied Oriental Medicine. 2007;7(1):27-34.
  21. Jeong-Ja, Kim, Bu Il Seo, Soon-Shik Shin. A comparative study on efficacy of Saponariae Vaccariae Semen and Melandryi Firmi Herba extracts on analgesic effects, anti-inflammatory effects and arthritis. The Journal of Applied Oriental Medicine. 2007;7(1):7-19.
  22. Yao P, Song F, Li K, Zhou S, Liu S, Sun X, Nussler AK, Liu L. Ginkgo biloba extract prevents ethanol induced dyslipidemia. Am J Chin Med. 2007;35(4):643-52. https://doi.org/10.1142/S0192415X07005132
  23. Whang TE, Lim HO, Lee JW. Effect of Fermented(Oenanthe stolonifera DC) Extract on the Activity of Enzymes Related to Liver Function of Alcohol-administered Rats and Mice. Korean J. Medicinal Crop. Sci. 1999;7(2):107-114.
  24. McBride P. Triglycerides and risk for coronary artery disease. Curr Atheroscler Rep. 2008 Oct;10(5):386-90. https://doi.org/10.1007/s11883-008-0060-9
  25. Lee CK, Choi JW, Kim HK and Han YN. Biological activities of acidic polysaccharide of Korean Red Ginseng. II.-Effects on hyperlipidemia induced by alcohol. J. Ginseng Res. 1999;23(1):8-12.
  26. Liangpunsakul S, Crabb DW, Qi R. Relationship among alcohol intake, body fat, and physical activity:a population-based study. Ann Epidemiol. 2010 Sep;20(9):670-5. https://doi.org/10.1016/j.annepidem.2010.05.014
  27. Tolstrup JS, Gronbaek M, Tybjaerg-Hansen A, Nordestgaard BG. Alcohol intake, alcohol dehydrogenase genotypes, and liver damage and disease in the Danish general population. Am J Gastroenterol. 2009 Sep;104(9):2182-8. Epub 2009 Jun 23. https://doi.org/10.1038/ajg.2009.370
  28. Yue M, Ni Q, Yu CH, Ren KM, Chen WX, Li YM. Transient elevation of hepatic enzymes in volunteers after intake of alcohol. Hepatobiliary Pancreat Dis Int. 2006 Feb;5(1):52-5.
  29. Chaung WW, Jacob A, Ji Y, Wang P. Suppression of PGC-1alpha by Ethanol: Implications of Its Role in Alcohol Induced Liver Injury. Int J Clin Exp Med. 2008;1(2):161-70. Epub 2008 Mar 21.
  30. Bu Il Seo, Deok Mo Gu, Jin-Hyun Park, Soon Joo Kwon. Effects of water extracts from Fugu rubripes rubripes with several herbs on hyperlipidemia and liver damage induced by alcohol. Kor. J. Herbology. 2003;18(4):301-308.