Biological and Antimicrobial Activity of Vaccinium oldhami Fruit

정금나무(Vaccinium oldhami) 열매의 생리활성 및 항균활성

This study was carried out to investigate the biological activity and antimicrobial activity of Vaccinium oldhami fruit extracts. ABTS radical cation decolorization and the antioxidant protection factor (PF) of extracts as $92.7{\pm}4.1%$ and $3.6{\pm}1.6$ PF were higher than a BHT of $200{\mu}g/mL$ as $52.4{\pm}1.9%$ and $2.0{\pm}0.8$ PF, and the TBARS of extracts was $74.4{\pm}2.9%$ with $200{\mu}g/mL$. The hypertension inhibitory activity of extracts from Vaccinium oldhami fruit indicated the activities of $28.6{\pm}0.6%$ with $200{\mu}g/mL$, and anti-gout activity was $43.3{\pm}0.8%$ with $200{\mu}g/mL$. Antimicrobial activity was found in Vaccinium oldhami fruit extracts on Helicobacter pylori, Staphylococcus epidermidis, Staphylococcus aureus, Eschericia coli and Propionebacterium acne. This activity was illustrated as 24 mm, 28 mm, 13 mm, 26 mm and 16 mm clear zones with $200{\mu}g/mL$ respectively, and the elastase inhibitory activity which is related to the wrinkle cause was observed in extracts as $52.7{\pm}0.9%$ with $200{\mu}g/mL$.

정금나무 열매의 생리활성 및 항균활성을 측정한 결과, ABTS radical decolorlization은 $200{\mu}g/mL$에 $92.7{\pm}4.1%$로 positive control인 BHA의 $200{\mu}g/mL$에서 $52.4{\pm}1.9%$보다 높은 활성을 보였다. 지용성 물질의 항산화력을 나타내는 TBARS값은 $200{\mu}g/mL$에서 $74.4{\pm}2.9%$, antioxidant protection factor는 $200{\mu}g/mL$에서 $3.6{\pm}1.6%$로 항산화효과가 우수한 것으로 나타났다. 정금나무 열매 추출물의 angiotensin converting enzyme 활성억제 효과는 $200{\mu}g/mL$에서 $28.6{\pm}0.6%$의 저해율을 나타내었으며, xanthine oxidase 저해활성을 측정한 결과 $200{\mu}g/mL$에서 $43.3{\pm}0.8%$ 이상의 활성을 나타내었다. 정금나무 열매 추출물의 항균활성을 측정한 결과 Helicobacter pylori는 $200{\mu}g$/0.1 mL 농도에서 24 mm의 저해환을 보였고, Staphylococcus epidermidis는 28 mm의 저해환을, Staphylococcus aureus, Eschericia coil, Propionebacterium acnes는 각각 13 mm, 26 mm, 16 mm의 저해환을 나타내어 $200{\mu}g$/0.1 mL의 농도 이상에서는 모두 항균활성이 나타나는 것을 확인할 수 있었다. 주름억제 효과를 나타내는 elastase 억제효과를 측정한 결과 $200{\mu}g/mL$에서 $52.7{\pm}0.9%$로 비교적 높은 활성을 나타내었다.