Korean Circulation Journal

The Korean Society of Cardiology (대한심장학회)
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Recurrent Deep Vein Thrombosis due to Thrombophilia

  • Rahman, Afzalur (Department of Cardiology, Sir Salimullah Medical College & Mitford Hospital) ;
  • Islam, AKM Monwarul (Department of Cardiology, National Institute of Cardiovascular Diseases) ;
  • Husnayen, SAM (Department of Cardiology, Zia Heart Foundation Hospital and Research Institute)
  • Published : 2012.05.31
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Abstract

Deep vein thrombosis (DVT) is a common condition that is often under-diagnosed. Acquired or hereditary defects of coagulation or a combination of these defects may facilitate the development of DVT. Recurrent DVT, a positive family history or unusual presentation may warrant investigation for hereditary thrombophilia. Investigations are best when conducted at least one month after completion of a course of anticoagulant therapy. Most patients are managed with heparin in the acute stage overlapped by warfarin. The case presented here describes a 40-year old man undergoing three episodes of DVT. Investigations revealed protein C and protein S deficiency. Protein C, protein S and antithrombin deficiency either singly or in combination, are relatively common causes of hereditary thrombophilia. The case presented here serves as a reminder of the need to look into the underlying cause of venous thromboembolism.

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References

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