The Korean Journal of Medicine

The Korean Association of Internal Medicine (대한내과학회)
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Isoniazid-Induced Acute Pancreatitis with Pseudocyst

Isoniazid에 의한 가성용종을 동반한 급성췌장염 1예

  • Cha, Byung-Hyo (Department of Internal Medicine, Cheju Halla Hospital) ;
  • Lee, Sang-Hyub (Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine) ;
  • Hwang, Jin-Hyeok (Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine) ;
  • Kim, Jang-Eon (Department of Internal Medicine, Seoul Citizen Hospital) ;
  • Lee, Sang-Jin (Department of Internal Medicine, Cheju Halla Hospital) ;
  • Lee, Chung-Sik (Department of Internal Medicine, Cheju Halla Hospital) ;
  • Kim, Hyun (Department of Internal Medicine, Halla Hospital)
  • 차병효 (제주한라병원 내과) ;
  • 이상협 (서울대학교 의과대학 분당서울대학교병원 내과) ;
  • 황진혁 (서울대학교 의과대학 분당서울대학교병원 내과) ;
  • 김장언 (서울시립의료원 내과) ;
  • 이상진 (제주한라병원 내과) ;
  • 이충식 (제주한라병원 내과) ;
  • 김현 (제주한라병원 영상의학과)
  • Published : 2012.05.01
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Abstract

Numerous medications have the potential to induce acute pancreatitis. However, isoniazid-induced acute pancreatitis is extremely rare. Drug-induced acute pancreatitis can be diagnosed by improvement after stopping the drug and recurrence of pancreatitis when rechallenged. We present a case of severe acute pancreatitis accompanied by multiple large pseudocysts after isoniazid treatment for pulmonary tuberculosis. We confirmed that isoniazid induced pancreatitis by rechallenging after treatment cessation. Most previous reports of isoniazid-induced pancreatitis have been clinically mild forms, and the patient fully recovered with supportive management. However, this case presents severe and permanent pancreatic damage that developed with 5 weeks of isoniazid treatment. When a patient presents with manifestations of pancreatitis during treatment of tuberculosis that includes isoniazid, the physician should consider isoniazid-induced pancreatitis.

Keywords

References

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