The Korean journal of internal medicine

  • 제27권1호
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  • Pages.66-71
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  • 2012
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  • 1226-3303(pISSN)
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  • 2005-6648(eISSN)
대한내과학회 (The Korean Association of Internal Medicine)
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Associations among Body Mass Index, Insulin Resistance, and Pancreatic ${\beta}-Cell$ Function in Korean Patients with New-Onset Type 2 Diabetes

  • Chung, Jin-Ook (Division of Endocrinology and Metabolism, Department of Internal Medicine, Chonnam National University Medical School) ;
  • Cho, Dong-Hyeok (Division of Endocrinology and Metabolism, Department of Internal Medicine, Chonnam National University Medical School) ;
  • Chung, Dong-Jin (Division of Endocrinology and Metabolism, Department of Internal Medicine, Chonnam National University Medical School) ;
  • Chung, Min-Young (Division of Endocrinology and Metabolism, Department of Internal Medicine, Chonnam National University Medical School)
  • 발행 : 2012.03.01
⟨ 이전 논문 다음 논문 ⟩

초록

Background/Aims: We investigated the associations among body mass index (BMI), insulin resistance, and ${\beta}-Cell$ function in Korean patients newly presenting with type 2 diabetes. Methods: In total, 132 patients with new-onset type 2 diabetes mellitus were investigated. A standard 75-g oral glucose tolerance test was performed, and the indices of insulin secretion and insulin resistance were calculated. Results: A higher BMI was associated with higher homeostasis model assessment values for insulin resistance (HOMAIR), homeostasis model assessment of ${\beta}-Cell$ function ($HOMA-{\beta}$), and insulinogenic index as well as lower levels of insulin sensitivity index composite ($ISI_{comp}$) and disposition index (DI). In multiple regression models, BMI had independent positive associations with HOMA-IR, $ISI_{comp}$, and $HOMA-{\beta}$ and inverse associations with the DI. Conclusions: Our results showed that BMI had independent positive associations with indices of insulin resistance and an inverse association with ${\beta}-Cell$ function adjusted for insulin resistance in Korean patients newly presenting with type 2 diabetes.

키워드

참고문헌

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