KSBB Journal

The Korean Society for Biotechnology and Bioengineering (한국생물공학회)
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The Evaluation of Antithrombotic and Fibrinolytic Activities of Nattokinase from Bacillus subtilis Natto

Bacillus subtilis Natto가 생산하는 Nattokinase의 항혈전 및 피브린 용해능 효능평가

  • 이다령 (연세대학교 의과대학 심혈관제품 유효성평가센터) ;
  • 홍성유 (연세대학교 의과대학 심혈관제품 유효성평가센터) ;
  • 장양수 (연세대학교 의과대학 심혈관제품 유효성평가센터) ;
  • 장형욱 (케이피엑스바이오텍(주)) ;
  • 맹창재 (케이피엑스바이오텍(주)) ;
  • 유철배 (케이피엑스바이오텍(주)) ;
  • 백대헌 (케이피엑스바이오텍(주))
  • Received : 20120000
  • Accepted : 20120000
  • Published : 2012.12.31
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Abstract

We previously reported that Ultra nattokinase$^{(R)}$ showed high fibrinolytic activity and revealed antithrombotic effect in rat blood plasma based on its ability to suppress collagen-induced platelet aggregation. This research was carried out to verify the clot lysing activity and blood flow enhancing effects of Ultra nattokinase$^{(R)}$ via monitoring and comparing the antithrombotic effects in rat artery between oral administration of Ultra nattokinase$^{(R)}$ and maltodextrin. SD rats were fed with 1.11 mg/kg of Ultra nattokinase$^{(R)}$ for 4 weeks. The effect on arterial thrombosis was then evaluated using an antithrombotic model after induction by $FeCl_3$. Detected fibrinolytic activity was proportional to the content of Ultra nattokinase$^{(R)}$ and statistical extents of the antithrombotic activity was enhanced strongly twice rather than control group. The PT and the aPTT, however, showed only a small difference between two groups. The results suggest that Ultra nattokinase$^{(R)}$ can effectively treat thromboembolism and enhance blood flow, and that Ultra nattokinase$^{(R)}$ can also prevent venous occlusion by aiding clot lysis.

Keywords

References

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