KSBB Journal

  • 제27권6호
  • /
  • Pages.325-329
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  • 2012
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  • 1225-7117(pISSN)
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  • 2288-8268(eISSN)
한국생물공학회 (The Korean Society for Biotechnology and Bioengineering)
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참모자반 (Sargassum fulvellum) 물 추출물의 염증 억제 활성

Anti-inflammatory Activity of the Water Extract of Sargassum fulvellum

  • 정다현 (부경대학교 식품공학과/식품연구소) ;
  • 김꽃봉우리 (부경대학교 수산과학연구소) ;
  • 강보경 (부경대학교 식품공학과/식품연구소) ;
  • 정슬아 (부경대학교 식품공학과/식품연구소) ;
  • 김현지 (부경대학교 식품공학과/식품연구소) ;
  • 정희예 (부경대학교 식품공학과/식품연구소) ;
  • 박시우 (부경대학교 식품공학과/식품연구소) ;
  • 안동현 (부경대학교 식품공학과/식품연구소)
  • Jeong, Da-Hyun (Department of Food Science & Technology/Institute of Food Science, Pukoung National University) ;
  • Kim, Koth-Bong-Woo-Ri (Institute of Fisheries Sciences/Pukyong National University) ;
  • Kang, Bo-Kyeong (Department of Food Science & Technology/Institute of Food Science, Pukoung National University) ;
  • Jung, Seul-A (Department of Food Science & Technology/Institute of Food Science, Pukoung National University) ;
  • Kim, Hyun-Jee (Department of Food Science & Technology/Institute of Food Science, Pukoung National University) ;
  • Jeong, Hee-Ye (Department of Food Science & Technology/Institute of Food Science, Pukoung National University) ;
  • Bark, Si-Woo (Department of Food Science & Technology/Institute of Food Science, Pukoung National University) ;
  • Ahn, Dong-Hyun (Department of Food Science & Technology/Institute of Food Science, Pukoung National University)
  • 투고 : 2012.10.31
  • 심사 : 2012.12.11
  • 발행 : 2012.12.31
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초록

The anti-inflammatory effects of Sargassum fulvellum water extracts (SFWE) were investigated using lipopolysaccharide (LPS)-induced inflammatory response in this study. To examine the potential anti-inflammatory properties of SFWE, the NO, TNF-${\alpha}$, IL-6, IL-$1{\beta}$, and cell proliferation were measured. It was confirmed that the NO and TNF-${\alpha}$ secretion were significantly suppressed when SFWE was added to LPS-stimulated RAW 264.7 cells. Moreover, the expression of IL-6 and IL-$1{\beta}$ cytokines was suppressed by SFWE in a dose-dependent manner. Especially, IL-6 inhibition activities were over 50% at 1% of SFWE. The cytotoxicity of SFWE and the proliferation of macrophages was measured by MTT assay. As a result, there was no cytotoxicity in the macrophage proliferation treated with SFWE compared to the control. In conclusion, these results suggested that the SFWE may have significant effects on inflammatory factors and can be a potential anti-inflammatory therapeutic materials.

키워드

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피인용 문헌

  1. Comparison Study of Immunomodulatory Activity of Polysaccharide and Ethanol Extracted from Sargassum fulvellum vol.44, pp.11, 2015, https://doi.org/10.3746/jkfn.2015.44.11.1621
  2. 채진목 에탄올 추출물의 항염증 효과 검증 vol.43, pp.1, 2012, https://doi.org/10.15230/scsk.2017.43.1.19
  3. Pharmaceutical and Nutraceutical Potential Applications of Sargassum fulvellum vol.2020, pp.None, 2012, https://doi.org/10.1155/2020/2417410