대한한의학방제학회지 (Herbal Formula Science)

  • 제20권2호
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  • Pages.93-102
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  • 2012
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  • 1229-1218(pISSN)
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  • 2288-5641(eISSN)
대한한의학방제학회 (The Korean Medicine Society for the Herbal Formula Study)
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구미강활탕 및 발효 구미강활탕 추출물의 급성독성 연구

Acute Toxicity Study on Gumiganghwal-tang and Fermented Gumiganghwal-tang Extracts

  • 박화용 (한국한의학연구원 한의신약연구그룹) ;
  • 황윤환 (한국한의학연구원 한의신약연구그룹) ;
  • 장두례 (한국한의학연구원 한의신약연구그룹) ;
  • 하정호 (한국한의학연구원 한의신약연구그룹) ;
  • 정기연 (한국한의학연구원 한의신약연구그룹) ;
  • 마진열 (한국한의학연구원 한의신약연구그룹)
  • Park, Hwayong (KM-Based Herbal Drug Research Group, Korea Institute of Oriental Medicine) ;
  • Hwang, Youn-Hwan (KM-Based Herbal Drug Research Group, Korea Institute of Oriental Medicine) ;
  • Jang, Doorye (KM-Based Herbal Drug Research Group, Korea Institute of Oriental Medicine) ;
  • Ha, Jeong-Ho (KM-Based Herbal Drug Research Group, Korea Institute of Oriental Medicine) ;
  • Jung, Kiyoun (KM-Based Herbal Drug Research Group, Korea Institute of Oriental Medicine) ;
  • Ma, Jin Yeul (KM-Based Herbal Drug Research Group, Korea Institute of Oriental Medicine)
  • 투고 : 2012.11.17
  • 심사 : 2012.12.04
  • 발행 : 2012.12.30
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초록

Objectives : Traditional medicine Gumiganghwal-tang (GT) has been used in Asia to treat inflammatory diseases including common cold, pain, fever, and algor. In this study we investigated the acute toxicity and safety of GT and fermented GT (FGT). Methods : Acute toxicity and safety were evaluated in male and female ICR mice orally administered 0 (control) and 2,000 mg/kg of GT and FGT. After the administration of GT and FGT, we observed mortality, body weight, clinical symptoms. After necropsy, organ weights were measured and blood analysis was performed. Results : There was no mortality and clinical symptoms according to the administration of GT and FGT. Comparing with control group, there were no significant alterations on the organ weight, complete blood cell count and biochemical parameters. Conclusions : Median lethal dose of GT and FGT considered to be over 2,000 mg/kg in both male and female mice, and recognized as safe with no toxicity.

키워드

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