Journal of Acupuncture Research

Korean Acupuncture & Moxibustion Medicine Society (대한침구의학회)
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The Effect of Junci Medulla Herbal-acupuncture at $KI_{10}$ on LPS induced Nephritis in Rats

음곡에 시술한 등심초약침이 LPS로 유도된 흰쥐의 신장염에 미치는 영향

  • Ihm, Jee Soon (Dept. of Meridian and Acupoint, College of Oriental Medicine, Daejeon University) ;
  • Cho, Tae Hwan (Dept. of Meridian and Acupoint, College of Oriental Medicine, Daejeon University) ;
  • Yim, Yun Kyoung (Dept. of Meridian and Acupoint, College of Oriental Medicine, Daejeon University)
  • 임지순 (대전대학교 한의과대학 경락경혈학교실) ;
  • 조태환 (대전대학교 한의과대학 경락경혈학교실) ;
  • 임윤경 (대전대학교 한의과대학 경락경혈학교실)
  • Received : 2012.11.12
  • Accepted : 2012.11.20
  • Published : 2012.12.20
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Abstract

Objectives : This study aimed to evaluate the effects of Junci Medulla Herbal-acupuncture(JM-HA) at $KI_{10}$(Umgok) on nephritis induced by lipopolysaccharide(LPS) in rats. Methods : Rats with nephritis induced by LPS, were treated with JM-HA at $KI_{10}$ 3 times a week. The rats in the NP group and the saline group were treated with a needle prick and a saline injection respectively. To evaluate the effects of JM-HA at $KI_{10}$ on nephritis in rats, WBC, neutrophils in blood, BUN, creatinine, TNF-${\alpha}$ in serum, creatinine, total protein in urine and renal MPO were measured. Results : JM-HA at $KI_{10}$ significantly inhibited the increase of WBC and neutrophils in blood, BUN, creatinine, TNF-${\alpha}$ in serum, and MPO in kidney of LPS-stimulated rats. Conclusion : JM-HA at $KI_{10}$ has therapeutic effects on nephritis in LPS-stimulated rats. Therefore, it is suggested that JM-HA at $KI_{10}$ may be a useful therapy in clinical field after further researches.

Keywords

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