셀메드 (CELLMED)

  • 제2권1호
  • /
  • Pages.9.1-9.13
  • /
  • 2012
  • /
  • 3022-6805(pISSN)
  • /
  • 3022-6791(eISSN)
셀메드 세포교정의약학회 (Cellmed Orthocellular Medicine and Pharmaceutical Association)
권호 표지
DOI QR코드

DOI QR Code

Therapeutic effects of traditional Korean medicine, Jeechool-Whan in allergic rhinitis model

  • Oh, Hyun-A (Department of Pharmacology, College of Oriental Medicine, Kyung Hee University) ;
  • Ryu, Jae-Gyu (Department of Pharmacology, College of Oriental Medicine, Kyung Hee University) ;
  • Cha, Wung-Seok (Department of Korean Medical History, College of Oriental Medicine, Kyung Hee University) ;
  • Kim, Hyung-Min (Department of Pharmacology, College of Oriental Medicine, Kyung Hee University) ;
  • Jeong, Hyun-Ja (Biochip Research Center, Hoseo University)
  • 투고 : 2011.05.21
  • 심사 : 2012.02.29
  • 발행 : 2012.02.29
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Jeechool-Whan (JW) is a prescription of Ponciri Fructus Immaturus and Atractylodis Rhizoma Alba and improves the functions of the stomach and the spleen. Although it is said in Korean Medicine that the spleen and the stomach are the roots of the body's resistance, the meaning of 'improving the spleen and the stomach' is very comprehensive. Moreover, there are lots of drugs that are said to improve the spleen and the stomach, and the number of prescriptions using these drugs is huge. In this study, we focused on the new effect and mechanism of the JW on the ovalbumin (OVA)-induced allergic rhinitis (AR) model. The increased number of rubs and the increased levels of IgE and histamine in the OVA-sensitized mice were inhibited by JW administration. The balance of Th1/Th2 cytokine level was regulated by JW administration. The levels inflammatory proteins were decreased by JW administration in the nasal mucosa of the OVA-sensitized mice. Eosinophils and mast cells infiltration increased by OVA-sensitization was also decreased in the JW-administered mice. In addition, JW inhibited caspase-1 activity in the same nasal mucosa tissue. In activated human mast cells, JW inhibited the receptor interacting protein-2, I${\kappa}$B kinase-${\beta}$, nuclear factor-${\kappa}$B/Rel A, and caspase-1 activation. In conclusion, this study will be support the clear understanding of the concept of the spleen and the stomach in traditional Korean medicine as well as for a possibility of finding a cure for this AR in traditional medical treatments.

키워드

참고문헌

  1. Albelda SM. Endothelial and epithelial cell adhesion molecules. Am J Respir Cell Mol Biol. 1991;4:195-203. https://doi.org/10.1165/ajrcmb/4.3.195
  2. Bach JF. The effect of infections on susceptibility to autoimmune and allergic diseases. N Engl J Med. 2002;347:911-920. https://doi.org/10.1056/NEJMra020100
  3. Bournazou I, Mackenzie KJ, Duffin R, Rossi AG, Gregory CD. Inhibition of eosinophil migration by lactoferrin. Immunol Cell Biol. 2010;88:220-223. https://doi.org/10.1038/icb.2009.86
  4. Bousquet J, Khaltaev N, Cruz AA, Denburg J, Fokkens WJ, Togias A, Zuberbier T, Baena-Cagnani CE, Canonica GW, van Weel C, et al. World Health Organization; GA (2) LEN; Allergen. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA (2) LEN and Allergen). Allergy. 2008;86:8-160.
  5. Calderon E, Lockey RF. A possible role for adhesion molecules in asthma. J Allergy Clin Immunol. 1992;90:852-865. https://doi.org/10.1016/0091-6749(92)90112-F
  6. Chang ML, Yang LL, Chang DM, Kuo SY, Chu SJ. The influence of Chinese traditional medicine on the production and activity of interleukin 1 (IL-1). Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi. 1993;26:15-24.
  7. Cha WS, Oh JH, Park HJ, Ahn SW, Hong SY, Kim NI. Historical difference between traditional Korean medicine and traditional Chinese medicine. Neurol Res. 2007;29 Suppl 1:S5-9.
  8. Chin AI, Dempsey PW, Bruhn K, Miller JF, Xu Y, Cheng G. Involvement of receptor-interacting protein 2 in innate and adaptive immune responses. Nature. 2002;416:190-194. https://doi.org/10.1038/416190a
  9. Choi K, Lee J, Yoo J, Lee E, Koh B, Lee. Sasang constitutional types can act as a risk factor for insulin resistance. J.Diabetes Res Clin Pract. 2011;91:57-60. https://doi.org/10.1016/j.diabres.2010.11.017
  10. Eum HA, Lee WY, Kim SH, Kim JY, Park SW, Lee JS, Choi SM, Pyo S, Kang MJ, Min YD, et al. Anti-inflammatory activity of CML-1: an herbal formulation. Am J Chin Med. 2005;33:29-40. https://doi.org/10.1142/S0192415X05002631
  11. Fuentes-Beltran A, Montes-Vizuet R, Valencia-Maqueda E, Negrete-García MC, García-Cruz Mde L, Teran LM. Chemokine CC-ligand 5 production and eosinophil activation into the upper airways of aspirin-sensitive patients. Clin Exp Allergy. 2009;39:491-499. https://doi.org/10.1111/j.1365-2222.2008.03190.x
  12. Fukui N, Honda K, Ito E, Ishikawa K. Peroxisome proliferator-activated receptor gamma negatively regulates allergic rhinitis in mice. Allergol Int. 2009;58:247-253. https://doi.org/10.2332/allergolint.08-OA-0047
  13. Grzegorczyk J, Kowalski ML, Pilat A, Iwaszkiewicz J. Increased apoptosis of peripheral blood mononuclear cells in patients with perennial allergic asthma/rhinitis: relation to serum markers of apoptosis. Mediators Inflamm. 2002;11:225-233. https://doi.org/10.1080/09629350290000087
  14. Gupta S, Feng L, Yoshimura T, Redick J, Fu SM., Rose CE. Intra-alveolar macrophage-inflammation peptide 2 induces rapid neutrophil localization in the lung. Am J Respir Cell Mol Biol. 1996;15:656-663. https://doi.org/10.1165/ajrcmb.15.5.8918372
  15. Guzman J, Izumi T, Nagai S, Costabel U. ICAM-1 and integrin expression on isolated human alveolar type II pneumocytes. Eur Respir. 1994;7:736-739. https://doi.org/10.1183/09031936.94.07040736
  16. Hellings PW, Fokkens WJ. Allergic rhinitis and its impact on otorhinolaryngology. Allergy. 2006;61:656-664. https://doi.org/10.1111/j.1398-9995.2006.01109.x
  17. Hirota RJ, Roger NN, Nakamura H, Song HS, Sawamura M, Suganuma N. Anti-inflammatory Effects of Limonene from Yuzu (Citrus junos Tanaka) Essential Oil on Eosinophils. J Food Sci. 2010;75:87-92. https://doi.org/10.1111/j.1750-3841.2010.01541.x
  18. Hong MH, Kim JH, Bae HS, Lee NY, Shin YC, Kim SH, Ko SG. Atractylodes japonica Koidzumi Inhibits the Production of Proinflammatory Cytokines through Inhibition of the NF-${\kappa}$B/I${\kappa}$B Signal Pathway in HMC-1 Human Mast Cells. Arch Pharm Res. 2010;33:843-851. https://doi.org/10.1007/s12272-010-0606-6
  19. Hosomi N, Fukai K, Nakanishi T, Funaki S, Ishii M. Caspase-1 activity of stratum corneum and serum interleukin-18 level are increased in patients with Netherton syndrome. Br J Dermatol. 2008;159:744-746.
  20. Howarth PH. Allergic and nonallergic rhinitis. In: Middleton E, Reed C, Ellis E, Adkinson N, Yunginger J, Busse W, eds. Allergy, Principles and Practice, vol. 2, Allergy, Principles and Practice. 6th ed. Philadelphia: Mosby. 2003;391-410.
  21. Inohara N, Koseki T, Lin J, del Peso L, Lucas PC, Chen FF, Ogura Y, Nunez G. An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways. J Biol Chem. 2000;275:27823-27831.
  22. Jeong HJ, Kim SJ, Kim HM, Um JY, Moon PD, Jun SM, Hong SH. Yulda-hanso-tang attenuates the endotoxin-induced inflammatory cytokine production in peripheral blood mononuclear cells. International Journal of Neuroscience. 2007;117(8):1149-1165. https://doi.org/10.1080/00207450600934580
  23. Jeong HJ, Moon PD, Kim SJ, Seo JU, Kang TH, Kim JJ, Kang IC, Um JY, Kim HM, Hong SH. Activation of hypoxia-inducible factor-1 regulates human histidine decarboxylase expression. Cell Mol Life Sci. 2009;66:1309-1319. https://doi.org/10.1007/s00018-009-9001-1
  24. Jeong MY, Lee JS, Lee JD, Kim NJ, Kim JW, Lim S. A combined extract of Cinnamomi Ramulus, Anemarrhenae Rhizoma and Alpiniae Officinari Rhizoma suppresses production of nitric oxide by inhibiting NF-kappaB activation in RAW 264.7 cells. Phytother Res. 2008;22:772-777. https://doi.org/10.1002/ptr.2361
  25. Johansson SG, Hiurihane JO, Bousquet J, Bruijnzeel-Koomen C, Dreborg S, Haahtela T, Kowalski ML, Mygind N, Ring J, van Cauwenberge P, et al. A revised nomenclature for allergy: an EAACI position statement from the EAACI nomenclature task force. Allergy. 2001;56:813-824. https://doi.org/10.1034/j.1398-9995.2001.t01-1-00001.x
  26. Kelsall B. Getting to the guts of NOD2. Nature medicine. 2005;11:383-384. https://doi.org/10.1038/nm0405-383
  27. Kim YS, Jeong HJ, Kim HM, Cho SH. Brief comparison of the mechanism of modern medicine and traditional medicine in neuronal cell death. TANG. 2011;1(1):e1.
  28. Kobayashi K, Inohara N, Hernandez LD, Galan JE, Nunez G, Janeway CA, Medzhitov R, Flavell RA. RICK/Rip2/CARDIAK mediates signaling for receptors of the innate and adaptive immune systems. Nature. 2002;416:194-199. https://doi.org/10.1038/416194a
  29. Kubo M, Ma S, Wu J, Matsuda H. Anti-inflammatory activities of 70% methanolic extract from Cinnamomi Cortex. Biol Pharm Bull. 1996;19:1041-1045. https://doi.org/10.1248/bpb.19.1041
  30. Lamkanfi M, Declercq W, Depuydt B. In Caspases-Their role in Cell death and cell survival (Los M, and Walczak H, ed). Landes Bioscience and Kluwer Academic, New York. 2003
  31. Lee SS, Won TB, Kim JW, Rhee CS, Lee CH, Hong SC, Min YG. Effects of Dexamethasone on the Expression of Transforming Growth Factor-b in the Mouse Model of Allergic Rhinitis. Laryngoscope. 2007;117:1323-1328. https://doi.org/10.1097/MLG.0b013e318064e84d
  32. Makino T, Furuta A, Fujii H, Nakagawa T, Wakushima H, Saito K, Kano Y. Effect of oral treatment of Perilla frutescens and its constituents on type-I allergy in mice. Biol Pharm Bull. 2001;24:1206-1209. https://doi.org/10.1248/bpb.24.1206
  33. Marlin SD, Springer TA. Purified intercellular adhesion molecular-1 (ICAM-1) is a ligand for lymphocyte function associated antigen-1 (LFA-1). Cell. 1987;51:813-819. https://doi.org/10.1016/0092-8674(87)90104-8
  34. Martinon F. NLRs join TLRs as innate sensors of pathogens. Trends Immunol. 2005;26:447-454. https://doi.org/10.1016/j.it.2005.06.004
  35. Montefort S, Holgate ST, Howarth PH. Leukocyte-endothelial adhesion molecules and their role in bronchial asthma and allergic rhinitis. Eur Respir J. 1994;6:1044-1054.
  36. Montuschi P, Sala A, Dahlen SE, Folco G. Pharmacological modulation of the leukotriene pathway in allergic airway disease. Drug Discov Today. 2007;12:404-412. https://doi.org/10.1016/j.drudis.2007.03.004
  37. Mosmann TR, Cherwinski H, Bond MW, Giedin MA, Coffman RL. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol. 1986;136:2348-2357.
  38. Osakabe N, Yasuda A, Natsume M, Sanbongi C, Kato Y, Osawa T, Yoshikawa T. Rosmarinic acid, a major polyphenolic component of Perilla frutescens, reduces lipopolysaccharide (LPS)-induced liver injury in D-galactosamine (D-GalN)-sensitized mice. Free Radic Biol Med. 2002;33:798-806. https://doi.org/10.1016/S0891-5849(02)00970-X
  39. Park SH, Kim MG, Lee SJ, Kim JY, Chae H. Temperament and Character Profiles of Sasang Typology in an Adult Clinical Sample. Evid Based Complement Alternat Med. 2009 Nov 17. [Epub ahead of print]
  40. Pawankar R, Lee KH, Nonaka M, Takizawa R. Role of mast cells and basophils in chronic rhinosinusitis. Clin Allergy Immunol. 2007;20:93-101.
  41. Sanbongi C, Takano H, Osakabe N, Sasa N, Natsume M, Yanagisawa R, Inoue K, Kato Y, Osawa T, Yoshikawa T. Rosmarinic acid inhibits lung injury induced by diesel exhaust particles. Free Radic Biol Med. 2003;34:1060-1069. https://doi.org/10.1016/S0891-5849(03)00040-6
  42. Sarkar A, Duncan M, Hart J, Hertlein E, Guttridge DC, Wewers MD. ASC directs NF-B activation by regulating receptor interaction protein-2 (RIP2) caspase-1 interactions. The journal of immunology. 2006;176:4979-4986. https://doi.org/10.4049/jimmunol.176.8.4979
  43. Sato Y, Ohta S, Sakurai N, Shinoda M. Studies on chemical protectors against radiation. XXVI. Protective effect of various extracts on crude drugs on skin injury induced by X-irradiation. Yakugaku Zasshi. 1989;109:113-118. https://doi.org/10.1248/yakushi1947.109.2_113
  44. Shin TY, Kim SH, Kim SH, Kim YK, Park HJ, Chae BS, Jung HJ, Kim HM. Inhibitory effect of mast cell-mediated immediate-type allergic reactions in rats by Perilla frutescens. Immunopharmacol Immunotoxicol. 2000;22:489-500. https://doi.org/10.3109/08923970009026007
  45. Skoner DP. Allergic rhinitis: definition, epidemiology, pathophysiology, detection, and diagnosis. J allergy Clin Immunol. 2001;108:2-8.
  46. Smith SJ, Piliponsky AM, Rosenhead F, Elchalal U, Nagler A, Levi-Schaffer F. Dexamethasone inhibits maturation, cytokine production and Fc epsilon RI expression of human cord blood-derived mast cells. Clin Exp Allergy. 2002;32:906-913. https://doi.org/10.1046/j.1365-2745.2002.01418.x
  47. Stutz A, Golenbock DT, Latz E. Inflammasomes: too big to miss. J Clin Invest. 2009;119:3502-3511. https://doi.org/10.1172/JCI40599
  48. Tachibana H, Kubo T, Miyase T, Tanino S, Yoshimoto M, Sano M, Yamamoto-Maeda M, Yamada K. Identification of an inhibitor for interleukin 4-induced epsilon germline transcription and antigen specific IgE production in vivo. Biochem Biophys Res Commun. 2001;280:53-60. https://doi.org/10.1006/bbrc.2000.4069
  49. Takano H, Osakabe N, Sanbongi C, Yanagisawa R, Inoue K, Yasuda A, Natsume M, Baba S, Ichiishi E, Yoshikawa T. Extract of Perilla frutescens enriched for rosmarinic acid, a polyphenolic phytochemical, inhibits seasonal allergic rhinoconjunctivitis in humans. Exp Biol Med. 2004;229:247-254. https://doi.org/10.1177/153537020422900305
  50. Tosi MF, Stark JM, Smith CW, Hamedani A, Gruenert DC, Infeld MD. Induction of ICAM-1 expression on human airway epithelial cells by inflammatory cytokines: Effects on neutrophils-epithelial cell adhesion. Am J Respir Cell Mol Biol. 1992;7:214-221. https://doi.org/10.1165/ajrcmb/7.2.214
  51. Whitcup SM. Recent advances in ocular therapeutics. Int Ophthalmol Clin. 2006;46:1-6.
  52. Woschnagg C, Rubin J, Venge P. Eosinophil cationic protein (ECP) is processed during secretion. J Immunol. 2009;183:3949-3954. https://doi.org/10.4049/jimmunol.0900509
  53. Yazdi AS, Guarda G, 'Ombrain MC, Drexler SK. Drexler SK. Inflammatory caspases in innate immunity and inflammation. J Innate Immun. 2010;2(3):228-237. https://doi.org/10.1159/000283688
  54. Yoo NJ, Park WS, Kim SY, Reed JC, Son SG, Lee JY, Lee SH. Nod1, a CARD protein, enhances pro-interleukin-1beta processing through the interaction with pro-caspase-1. Biochem Biophys Res Commun. 2002;299:652-658. https://doi.org/10.1016/S0006-291X(02)02714-6

피인용 문헌

  1. Evaluation on Efficacy of Modern Medicine Ketotifen Using Traditional Delivery Science Acupuncture in Allergic Animal Models vol.24, pp.2, 2014, https://doi.org/10.1016/S1773-2247(14)50038-X
  2. The critical role of mast cell-derived hypoxia-inducible factor-1α in human and mice melanoma growth vol.132, pp.11, 2013, https://doi.org/10.1002/ijc.27937
  3. Socioeconomic impact of traditional Korean medicine, Pyeongwee-San (KMP6) as an anti-allergic inflammatory drug vol.2, pp.3, 2012, https://doi.org/10.5667/tang.2012.0027
  4. Effects of schizandrin on the expression of thymic stromal lymphopoietin in human mast cell line HMC-1 vol.91, pp.11-12, 2012, https://doi.org/10.1016/j.lfs.2012.08.009
  5. The (2′S,7′S)-O-(2-methylbutanoyl)-columbianetin as a novel allergic rhinitis-control agent vol.98, pp.2, 2014, https://doi.org/10.1016/j.lfs.2014.01.003
  6. Anti-fatigue effects of porcine placenta and its amino acids in a behavioral test on mice vol.92, pp.11, 2014, https://doi.org/10.1139/cjpp-2014-0068
  7. Protective Effects of Rutin through Regulation of Vascular Endothelial Growth Factor in Allergic Rhinitis vol.29, pp.3, 2015, https://doi.org/10.2500/ajra.2015.29.4195
  8. The role of thymic stromal lymphopoietin on mast cell-mediated allergic inflammatory reactions vol.6, pp.3, 2016, https://doi.org/10.5667/tang.2016.0021
  9. An osteoclastogenesis system, the RANKL/RANK signalling pathway, contributes to aggravated allergic inflammation vol.176, pp.11, 2012, https://doi.org/10.1111/bph.14615
  10. Biofabrication of silver nanoparticles using Ostericum koreanum plant extract for treatment of allergic rhinitis in nursing care vol.8, pp.1, 2012, https://doi.org/10.1088/2053-1591/abd4b5