사상체질의학회지 (Journal of Sasang Constitutional Medicine)

  • 제24권4호
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  • Pages.51-61
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  • 2012
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  • 1226-4075(pISSN)
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  • 2287-786X(eISSN)
사상체질의학회 (The Society Of Sasang Constitutional Medicine)
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사상 체질 처방의 항동맥경화 효능 비교 연구 -열다한소탕, 양격산화탕, 청심연자탕, 태음조위탕-

Anti-atherosclerotic Effects of Herbal Formulas for Sasang Constitutional Medicine

  • 김온순 (한국한의학연구원 한약기초연구그룹) ;
  • 김예지 (한국한의학연구원 한약기초연구그룹) ;
  • 신현규 (한국한의학연구원 한약기초연구그룹)
  • Kim, Ohn-Soon (Basic Herbal Medicine Research Group, Korea Institute of Oriental Medicine) ;
  • Kim, Ye-Ji (Basic Herbal Medicine Research Group, Korea Institute of Oriental Medicine) ;
  • Shin, Hyeun-Kyoo (Basic Herbal Medicine Research Group, Korea Institute of Oriental Medicine)
  • 투고 : 2012.10.08
  • 심사 : 2012.11.28
  • 발행 : 2012.12.31
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초록

Objectives : The purpose of this study was to investigate the anti-atherosclerotic effects of 4 herbal formulas for Sasang constitutional medicine (Yeoldahanso-tang: YDHST, Yanggyeoksanhwa-tang: YGSHT, Cheongsimyeonja-tang: CSYJT and Taeeumjowi-tang: TEJWT). Methods : The antioxidant activities of herbal formulas were studied by measuring free radical scavenging activities on ABTS and DPPH. The inhibitory effects on LDL oxidation was evaluated by the formation of TBARS, REM and fragmentation of apolipoprotein B-100 (ApoB). Effects of herbal formulas on macrophage lipid accumulation were determined in native LDL and LPS co-incubated macrophages using Oil Red O staining. Results : The scavenging activities on ABTS and DPPH of herbal formulas were increased in dose-dependent manner (YDHST>YGSHT>CSYJT>TEJWT). Herbal formulas reduced the oxidation properties of LDL induced by $CuSO_4$. YDHST, YGSHT and CSYJT showed strong suppressive effect on LDL oxidation than TEJWT. In addition, YDHST, YGSHT and CSYJT significantly inhibited foam cell formation in LDL/LPS stimulated RAW 264.7 cells. Conclusions : These results demonstrate that YDHST, YGSHT and CSYJT have potentials on anti-atherosclerosis by antioxidative effect and suppressive effect on LDL oxidation.

키워드

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피인용 문헌

  1. Review of Studies on Taeumin Yeoldahanso-tang since 2000 vol.26, pp.1, 2014, https://doi.org/10.7730/JSCM.2014.26.1.098
  2. Comparison of Effects of Yangkyuksanhwa-tang, Palmulgunja-tang and Cheongpyesagan-tang on the Rat Hyperthyroidism Induced by Levothyroxine vol.28, pp.2, 2016, https://doi.org/10.7730/JSCM.2016.28.2.132
  3. Protective effect of yeoldahanso-tang on radiation-induced oral mucositis in mice vol.16, pp.1, 2016, https://doi.org/10.1007/s13596-015-0211-9