Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Single-Dose Oral Toxicity of Fermented Scutellariae Radix Extract in Rats and Dogs

  • Kim, Myoung-Seok (Jeollanamdo Development Institute of Traditional Korean Medicine) ;
  • Ham, Seoung-Ho (Jeollanamdo Development Institute of Traditional Korean Medicine) ;
  • Kim, Jun-Ho (Jeollanamdo Development Institute of Traditional Korean Medicine) ;
  • Shin, Ji-Eun (Jeollanamdo Development Institute of Traditional Korean Medicine) ;
  • Oh, Jin (Jeollanamdo Development Institute of Traditional Korean Medicine) ;
  • Kim, Tae-Won (Laboratory of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Chungnam National University) ;
  • Yun, Hyo-In (Laboratory of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Chungnam National University) ;
  • Lim, Jong-Hwan (Laboratory of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Chungnam National University) ;
  • Jang, Beom-Su (Advanced Radiation Technology Institute/Korea Atomic Energy Research Institute) ;
  • Cho, Jung-Hee (Jeollanamdo Development Institute of Traditional Korean Medicine)
  • Received : 2012.09.21
  • Accepted : 2012.11.26
  • Published : 2012.12.31
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Abstract

The aim of this study was to investigate the acute oral toxicity of fermented Scutellariae Radix (JKTMHGu-100) in rats and dogs. JKTM-HGu-100 was orally administered at a dose of 2,000 mg/kg in Sprague-Dawley rats. An escalating single-dose oral toxicity test in beagle dogs was performed at doses of 500, 1000, and 2000 mg/kg with 4-day intervals. Clinical signs, changes in body weight, mortality, and necropsy findings were examined for 2 weeks following oral administration. No toxicological changes related to the test substance nor mortality was observed after administration of a single oral dose of JKTM-HGu-100 in rats or dogs. Therefore, the approximate lethal dose (LD) for oral administration of JKTMHGu-100 in rats was considered to be over 2,000 mg/kg, and the maximum tolerance doses (MTDs) in rats and dogs were also estimated to be over 2,000 mg/kg. These results indicate that JKTM-HGu-100 shows no toxicity in rodents or non-rodents at doses of 2,000 mg/kg or less.

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References

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