Toxicological Research

  • 제28권4호
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  • Pages.249-253
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  • 2012
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  • 1976-8257(pISSN)
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  • 2234-2753(eISSN)
한국독성학회 (Korean Society of Toxicology & Korea Environmental Mutagen Society)
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Anti-inflammatory Effect of Bumblebee Alcohol Extracts in CFA-Induced Rat Edema

  • Ahn, Mi Young (Department of Agricultural Biology, National Academy of Agricultural Science, RDA) ;
  • Han, Jea Woong (Department of Agricultural Biology, National Academy of Agricultural Science, RDA) ;
  • Yoon, Hyung Joo (Department of Agricultural Biology, National Academy of Agricultural Science, RDA) ;
  • Hwang, Jae Sam (Department of Agricultural Biology, National Academy of Agricultural Science, RDA) ;
  • Yun, Eun Young (Department of Agricultural Biology, National Academy of Agricultural Science, RDA)
  • 투고 : 2012.08.30
  • 심사 : 2012.11.26
  • 발행 : 2012.12.31
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초록

In this study, we prepared alcohol extracts of the larva, pupa, queen, and cocoon (clony) of B. ignitus, B. terrestris, and B. h. sapporoensis, and tested the anti-inflammatory activity of the extracts by using a rat model of adjuvant-induced edema. The extracts derived from the queen of B. ignitus, the queen of B. terrestris, and the cocoon of B. ignitus decreased hind paw edema after 1 day of i.p. administration. These extracts also induced vasorelaxation and NO production in calf pulmonary artery endothelial cells. These results suggest that bumblebee alcohol extracts has anti-inflammatory and vasorelaxant properties.

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참고문헌

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