The Korean Journal of Food And Nutrition (한국식품영양학회지)

The Korean Society of Food and Nutrition (한국식품영양학회)
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Study on the Proper D-Xylose Concentration in Sugar Mixture to Reduce Glycemic Index (GI) Value in the Human Clinical Model

설탕에 대한 Glycemic Index(GI) 저감효과가 있는 D-Xylose의 적정 농도에 관한 연구

  • Received : 2012.08.30
  • Accepted : 2012.11.05
  • Published : 2012.12.31
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Abstract

The objective of this study was to investigate the proper concentration of D-xylose which is expected to reduce the GI (Glycemic index) value of sucrose in the human body. When subjects took a sucrose mixture containing 5% and 10% D-xylose, the blood glucose levels were lowered by approximately 27.5% and 25.9%, respectively, compared to those of sucrose. The GI values of sucrose mixtures containing 5% and 10% D-xylose were 49.3 and 50.4, respectively. The reduction in GI value was not dependent on the D-xylose concentration, as the GI value of sucrose mixture containing 5% D-xylose (XyloSugar) was similar to that of sucrose mixture containing 10% D-xylose (XyloSugar10). D-xylose is not only more expensive but also less sweet than sucrose. So, low concentration of D-xylose has the advantage in the price and taste. It was determined that the proper concentration of D-xylose expected to reduce GI value of sucrose was 5% (w/w).

본 연구의 목적은 설탕의 Glycemic index(GI) 저감효과를 기대할 수 있는 D-xylose의 적정 농도를 조사하는 것이다. 그 결과, 5% D-xylose 첨가 설탕의 GI는 일반설탕의 GI 수치인 68에 비해 약 27.5% 낮은 49.3이었으며, 10% D-xylose 첨가 설탕의 GI는 약 25.9% 낮은 50.4로 확인되었다. D-xylose 첨가 설탕의 GI는 D-xylose의 농도 증가에 따라 의존적으로 감소하지는 않는 것으로 확인되었으며, 5% D-xylose 첨가 설탕(XyloSugar)의 GI 저감효과가 10% D-xylose 첨가 설탕(XyloSugar10)의 GI 저감효과와 차이가 없음을 확인하였다. D-xylose는 설탕에 비해 고가일 뿐만 아니라 감미도도 설탕보다 낮다. 그러므로 D-xylose의 농도가 낮을수록 가격, 맛에 있어서 장점이 있다. 따라서 설탕의 GI 저감효과를 기대할 수 있는 D-xylose의 적정 농도는 5%(w/w)로 판단된다.

Keywords

References

  1. Asano T, Yoshmura Y, Kunugita K. 1996. Sucrase inhibitory activity of D-xylose and effect on the elevation of blood glucose in rats. J Jpn Soc Nutr Food Sci 49:157-162 https://doi.org/10.4327/jsnfs.49.157
  2. Bae YJ, Bak YK, Kim BS, Kim MS, Lee JH, Sung MK. 2011. Coconut-derived D-xylose affects postprandial glucose and insulin responses in healthy individuals. Nutr Res Pract 5:533-539 https://doi.org/10.4162/nrp.2011.5.6.533
  3. Barclay AW, Brand-Miller J. 2011. The Australian paradox: A substantial decline in sugars intake over the same timeframe that overweight and obesity have increased. Nutrients 3:491-504 https://doi.org/10.3390/nu3040491
  4. Bischoff H. 1995. The mechanism of $\alpha$-glucosidase inhibition in the management of diabetes. Clin Invest Med 18:303-31
  5. Brand-Miller JC, Haholt S, Pawlak DB, McMillan J. 2002. Glycemic index and obesity. Am J Clin Nutr 76:281-285 https://doi.org/10.1093/ajcn/76.1.281S
  6. Brand Miller JC. 1994. Importance of glycemin index in diabetes. Am J Clin Nutr 59:747S-752S https://doi.org/10.1093/ajcn/59.3.747S
  7. Campbell D. 2011. Experts call for 10% 'fat tax' on soft drinks to prevent obesity. The Guardian. Wednesday 21 December 2011 16.59 GMT
  8. Foster-Powell K, Holt SH, Brand-Miller JC. 2002. International table of glycemic index and glycemic load values: 2002. Am J Clin Nutr 76:5-56 https://doi.org/10.1093/ajcn/76.1.5
  9. Frost G, Leeds AA, Dore CJ, Madeiros S, Brading S, Dornhorst A. 1999. Glycaemic index as a determinant of serum HDLcholesterol concentration. Lancet 353:1045-1048 https://doi.org/10.1016/S0140-6736(98)07164-5
  10. Hauri H, Wacker H, Rickli E, Meier B, Quaroni A, Semenza G. 1982. Biosynthesis of sucrase-isomaltase. J Biol Chem 257: 4522-4528
  11. Hodge AM, O'dea K, English DR, Giles GG. 2004. Glycemic index and dietary fiber and the risk of type 2 diabetes. Diabetes Care 27:2701-2706 https://doi.org/10.2337/diacare.27.11.2701
  12. Homler BE. 1984. Properties and stabililty of aspartame. Food Technol 38:50-55
  13. Jenkins DJ, Jenkins Al. 1995. Nutrition principles and diabetes. A role for "lente carbohydrate?" Diabetes Care 18:1491-1498 https://doi.org/10.2337/diacare.18.11.1491
  14. Jenkins DJ, Wolever TM, Taylor RH, Barker H, Fielder H, Baldwin JM, Bowling AC, Newman HC, Jenkins Al, Goff DV. 1981. Glycemic index of food: A physiological basis for carbohydrate exchange. Am J Clin Nutr 34:362-366 https://doi.org/10.1093/ajcn/34.3.362
  15. Kim KY, Nam KA, Kurihara H, Kim SM. 2008. Potent aglucosidase inhibitors purified from the red alga Grateloupia elliptica. Phytochemistry 69:2820-2825 https://doi.org/10.1016/j.phytochem.2008.09.007
  16. Krog-Mikkelsen I, Hels O, Tetens I, Holst JJ, Andersen JR, Bukhave K. 2011. The effects of L-arabinose on intestinal sucrase activity: Dose-response studies in vitro and in humans. Am J Clin Nutr 94:447-453
  17. Lee C, Shin JS. 2002. The effect of dietary fiber content of rice on the postprandial serum glucose response in normal subject. Korean J Food & Nutr 15:173-177
  18. Lee MH, Lee JS, Lee TH, Koo JG, Lee YC, Jeong SW, Nahmgung B, Yang HC. 2009. Effects of added buckwheat (Fagopyrum esculentum) extract on starch hydrolysis in vitro and glucose responses in healthy subjects. Korean J Food & Nutr 22:625-632
  19. Ludwig DS. 2000. Dietary glycemic index and obesity. J Nutr 130:280S-283S https://doi.org/10.1093/jn/130.2.280S
  20. Liu S, Willett WC, Stampfer MJ, Hu FB, Franz M, Sampson L, Hennekens CH, Manson JE. 2000. A prospective study of dietary glycemic load, carbohydrate intake, and risk of coronary heart disease in US women. Am J Clin Nutr 71:1455-1461 https://doi.org/10.1093/ajcn/71.6.1455
  21. Matsui T, Yoshimoto C, Osajima K, Oki T, Osajima Y. 1996. In vitro survey of $\alpha$-glucosidase inhibitory food components. Biosci Biotechnol Biochem 60:2019-2022 https://doi.org/10.1271/bbb.60.2019
  22. Nam SJ, Kim KO. 1989. Characteristics of Sikhye (Korean traditional drink) made with different amount of cooked rice and malt and with different sweeteners. Korean J Food Sci Technol 21:197-202
  23. Nelson AL. 2000. Sweeteners: Alternative. Properties of High Intensity Sweeteners. pp.17-29. Eagan Press, St. Paul, MN, USA
  24. Nelson AL. 2000. Sweeteners: Alternative. Special Topics. pp. 91-95. Eagan Press, St. Paul, MN, USA
  25. Oki T, Matsui T, Osajima Y. 1999. Inhibitory effect of $\alpha$- glucosidase inhibitors varies according to its origin. J Agric Food Chem 47:550-553 https://doi.org/10.1021/jf980788t
  26. Park SM, Lee SR. 1992. Estimation of the total dietary intake of saccharin by Korean population. Korean J Food Sci Technol 24:563-567
  27. Parnell W, Wilson N, Alexander D, Wohlers M, Williden M, Mann J, Gray A. 2008. Exploring the relationship between sugars and obesity. Public Health Nutr 11:860-866
  28. Pong L, Johnson JM, Barbeau We, Stewart DL. 1991. Evaluation of alternative fat and sweetener systems in cupcakes. Cereal Chem 68:552-555
  29. Puls W, Keup U. 1975. Inhibition of sucrase by Tris in rat and man, demonstrated by oral loading tests with sucrose. Metabolism 24:93-98 https://doi.org/10.1016/0026-0495(75)90010-4
  30. Saito N, Sakai H, Sekihara H, Yajima Y. 1998. Effect of an a-glucosidase inhibitor (voglibose), in combination with sulphonilureas, on glycaemic control in type 2 diabetes patients. J Int Med Res 26:219-232 https://doi.org/10.1177/030006059802600501
  31. Salmeron J, Manson JE, Stampfer MJ, Colditz GA, Wing AL, Willett WC. 1997. Dietary fiber, glycemic load, and risk of non-insulin-dependent diabetes mellitus in women. JAMA. 277:462-467
  32. Seri K, Sanai K, Matsuo N, Kawakubo K, Xue C, Inoue S. 1996. L-Arabinose selectively inhibits intestinal sucrase in an uncompetitive manner and suppresses glycemic response after sucrose ingestion in animals. Metabolism 145:1368-1374
  33. Stanik S, Marcus R. 1980. Insulin secretion improves following dietary control of plasma glucose in severely hyperglycemic obese patients. Metabolism 29:346-350 https://doi.org/10.1016/0026-0495(80)90008-6
  34. Toeller M. 1994. $\alpha$-Glucosidase inhibitors in diabetes: Efficacy in NIDDM subjects. Eur J Clin Invest 24:31-35
  35. Wolever TM, Jenkins DJ, Jenkins AL, Josse RG. 1991. The glycemic index method ology and clinical implication. Am J Clin Nutr 51:846-854
  36. Wolever TM, Jenkins DJ, Vuksan V, Jenkins AL, Wong GS, Josse RG. 1992. Benefical effect of low-glycemic index diet in overweight NIDDM subjects. Diabetes Care 15:562-564 https://doi.org/10.2337/diacare.15.4.562
  37. Ziambaras T, Rubin DC, Perlmutter DH. 1996. Regulation of sucrase-isomaltase gene expression in human intestinal epithelial cells by inflammatory cytokines. J Biol Chem 271:1237-1242 https://doi.org/10.1074/jbc.271.2.1237
  38. (주)네오뉴트라. 2012. Glycemic index (GI) 연구 보고서 - '자일로슈가, 자일로슈가10'-

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