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Protective effect of Tranilast on radiation-induced heart fibrosis in C57BL/6 mouse

  • Moon, Seongkwon (Radiation Oncology, College of Medicine, Soonchunhyang University Bucheon Hospital)
  • Received : 2012.09.13
  • Accepted : 2012.12.19
  • Published : 2012.12.28
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Abstract

The heart is a major dose-limiting organ for radiotherapy of cancer in the thoracic region. The purpose of this study was to examine the protective effect of tranilast on the radiation-induced heart fibrosis model using the C57BL/6 murine strain. A significant reduction in the expression of TGF-${\beta}1$, collagen type I and collagen type III was observed in the radiation plus tranilast group. The authors also suggest the use of tranilast in a clinical trial for the prevention of radiation-induced heart fibrosis.

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References

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