Pediatric Infection and Vaccine

The Korean Society of Pediatric Infectious Diseases (대한소아감염학회)
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A Case of Reye Syndrome Following Treatment of Kawasaki Disease with Aspirin

가와사키병 치료를 위한 아스피린 사용 후 발생한 라이 증후군 1예

  • Lee, Joon Kee (Department of Pediatrics, Seoul National University College of Medicine) ;
  • Kang, Ji Eun (Department of Pediatrics, Seoul National University Children's Hospital) ;
  • Choi, Eun Hwa (Department of Pediatrics, Seoul National University College of Medicine) ;
  • Choi, Jung Yun (Department of Pediatrics, Seoul National University College of Medicine)
  • 이준기 (서울대학교 의과대학 소아과학교실) ;
  • 강지은 (서울대학교병원 소아청소년과) ;
  • 최은화 (서울대학교 의과대학 소아과학교실) ;
  • 최정연 (서울대학교 의과대학 소아과학교실)
  • Received : 2012.04.13
  • Accepted : 2012.06.03
  • Published : 2012.08.25
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Abstract

Reye syndrome is a rapidly progressive encephalopathy with hepatic dysfunction, which often begins several days after apparent recovery from a viral illness, especially varicella or influenza A or B. Salicylate use was identified as a major precipitating factor for the development of Reye syndrome. With the recommendation to avoid use of salicylates in children, Reye syndrome has virtually disappeared in recent years. We report a case of Reye syndrome in a 5-month-old infant who had been treated with intravenous immunoglobulin and aspirin under the diagnosis of Kawasaki disease, and showed symptoms of sudden onset of irritability, rigidity, decreased activity, vomiting, poor appetite, lethargy, liver dysfunction without jaundice, coagulopathy, and hyperammonemia.

라이 증후군은 간부전을 동반하며 급속히 진행하는 뇌증으로, 인플루엔자와 수두 바이러스 등에 감염된 어린이에게 발병한다. 아스피린이 주된 원인 인자로 알려진 이후 소아에서 아스피린의 사용을 줄이면서 현재는 매우 드물게 보고 되고 있다. 저자들은 가와사키병 치료를 위해 정맥내 면역글로불린을 투여받고 아스피린을 복용하던 중 보챔, 강직, 활동량 저하, 식욕 저하, 처짐, 구토, 간수치 상승, 혈액 응고 장애와 고암모니아혈증으로 치료받은 5개월 여아를 보고하는 바이다.

Keywords

References

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