Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Disorder of Sexual Development in a Cocker Spaniel Dog: Sry-negative XX Sex Reversal

코커 스파니엘 개에서 발생한 성-발달장애: Sry-negative XX 성전환

  • Lee, Sung-Lim (Research Institute of Life Sciences, College of Veterinary Medicine, Gyeongsang National University) ;
  • Maeng, Geun-Ho (Research Institute of Life Sciences, College of Veterinary Medicine, Gyeongsang National University) ;
  • Kim, Na-Hyun (Department of Pathobiology, College of Veterinary Medicine, Konkuk University) ;
  • Park, Ki-Tae (Research Institute of Life Sciences, College of Veterinary Medicine, Gyeongsang National University) ;
  • Lee, Hee-Chun (Research Institute of Life Sciences, College of Veterinary Medicine, Gyeongsang National University) ;
  • Lee, Jae-Hoon (Research Institute of Life Sciences, College of Veterinary Medicine, Gyeongsang National University)
  • 이성림 (경상대학교 생명과학연구원) ;
  • 맹근호 (경상대학교 생명과학연구원) ;
  • 김나현 (건국대학교 수의과대학) ;
  • 박기태 (경상대학교 생명과학연구원) ;
  • 이희천 (경상대학교 생명과학연구원) ;
  • 이재훈 (경상대학교 생명과학연구원)
  • Accepted : 2012.10.18
  • Published : 2012.10.31
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Abstract

A 3-year-old Cocker spaniel was presented for evaluation because of a mass protruding from the vulva. This mass confirmed the presence of an internal bone in clitoris on the radiography. We recommended to the owner of the surgical removal of the gonads and uterus as well as the excision of the enlarged clitoris and os clitoris. The dog had gonads in the region of where the ovaries were located and presented what appeared to be a bicornate uterus and ductus deferens. Histological analysis revealed a morphologically normal uterus and two testes with their epididymis and ductus deferens. Karyotyping revealed a normal female chromosome constitution (78, XX), and polymerase chain reaction (PCR) identified the absence of Sry. Based on these findings, the patient was diagnosed with Sry-negative XX sex reversal.

3세령 코커 스파니엘 개가 질의 종괴를 평가하기 위해서 내원하였다. 이 종괴는 방사선 상에서 음경골이 있는 음핵이 확인 되었다. 생식선과 확장된 음핵의 제거를 보호자에게 추천하였다. 수술적으로 제거하는 동안 정관과 자궁 둘 다 관찰 되었으며, 난소가 있어야 할 곳에서 정소형태의 생식선이 관찰 되었다. 조직병리학적인 평가에서 정상적인 자궁과 고환과 부고환조직, 정관이 확인 되었다. 핵형분석에서는 정상적인 암컷의 염색체 (78, XX)를 보였고, PCR에서 Sry 가 나타나지 않았다. 이 결과들을 바탕으로 본 환축은 Sry-negative XX 성전환으로 진단되었다.

Keywords

References

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