Journal of the Korea Academia-Industrial cooperation Society (한국산학기술학회논문지)

The Korea Academia-Industrial cooperation Society (한국산학기술학회)
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The changes of cerebral blood flow by brain imaging algorithm in the Normal Brains : Analysis by Statistical Parametric Mapping

정상 뇌혈류 영상에서 재구성 알고리즘 적용에 따른 섭취율 차이 : 통계적 파라미터 지도를 사용한 분석

  • Lee, Hyo-Yeong (Department of Nuclear Medicine, Pusan National University Hospital) ;
  • Kim, Yun-Jin (Department of Family Medicine, Pusan National University Hospital) ;
  • Sin, Sung-Gyu (Department of Radiology, Dong-A University Medical Center)
  • 이효영 (부산대학교병원 핵의학과) ;
  • 김윤진 (부산대학교병원 가정의학과) ;
  • 신성규 (동아의료원 영상의학과)
  • Received : 2012.08.17
  • Accepted : 2012.11.08
  • Published : 2012.11.30
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Abstract

Single Photon Emission Computed tomography(SPECT) was performed on 13 healthy adults (average age: 39) to investigate the changes of cerebral blood flow according to brain imaging analysis algorithm. The acquired images were filtered and reconstructed through Filtered Back Projection (FBP) and Ordered Subset Expectation Maximization (OSEM). The brain distribution data of radiopharmaceuticals were compared using Statistical Parametric Mapping (SPM), and the changes of blood flow was expressed in Cluster. As a result, uptake rate was increased in Sub-gyral, Sub-Lobar, Extra-Nuclear, Limbic lobe and Cingulate Gyrus, while uptake rate was decreased in Middle frontal gyrus, Inferior Frontal Gyrus and Precentral Gyrus. The discriminable SPM was shown according to cerebral blood flows in Cluster by the reconstruction algorithm.

뇌 영상분석 알고리즘 적용에 따른 뇌혈류의 변화를 관찰하기 위해 정상 성인 13명(평균연령 39세)을 대상으로 뇌혈류 단 광자 단층촬영(Single Photon Emission Computed Tomography, SPECT)을 시행하였다. 획득된 영상을 여과후 역투영법(Filtered Back Projection, FBP)과 반복적 방법(Ordered Subset Expectation Maximization, OSEM)으로 영상을 재구성하여 통계학적 파라미터 뇌지도법으로 비교하여 방사성 의약품의 뇌 분포양상을 확인하였으며, 혈류의 변화는 크러스트(Cluster)로 표현시켰다. 이에 대한 결과로는 여과후 역투영법이 반복적 방법보다 섭취가 증가된 부위는 우측 전두엽, 대뇌회전하부, 외핵, 좌측대뇌 변엽과 대상이랑이며, 섭취가 감소된 부위는 좌측전두엽, 중간전두이랑, 하측전두이랑, 중심전이랑, 하측전두이랑, 중심전이랑이었다. 이는 영상재구성시 적용되는 알고리즘에 따라 뇌 혈류분포가 다르게 나타난 것을 크러스트(Cluster)로 표현시켰고, 명확한 시각적 표시가 가능하도록 뇌 확룔 지도로 보여주는데 의의가 있다.

Keywords

References

  1. Statistics Korea. Cause of Death, Statistical Results 11-12:2011
  2. Lee BC, Yu KH. Epidemiology of stroke in korea. J korea Med Assoc 45:1415-21;2002 https://doi.org/10.5124/jkma.2002.45.12.1415
  3. Choi YY, Kim JM, Kim KM, Choi IS, Utility of Acetazolamide-Enhanced brain perfusion SPECT in predicting outcome of the patients with aneurysmal subarachnoid hemorrhage. Korea J Nucl Med 35:241-50;2001
  4. Friston KJ, "Statistical parameteric mapping. In Functional Neuroimaging" (R, W. Thatcher, M, Hallet, T. Zeffiro, E, R, John, and M.HUERTA, Eds,). Academic Press, San Diego, pp, 79-93, 1994
  5. Friston KJ , Holmes AP, Worsley KJ, Poline J-P, et al, "Statistical parameteric maps in functional imaging : A general linear approach" HBM, pp, 189-210, 1995
  6. Hudson HM, Larkin RS, "Accelarated Image Reconstruction Using Ordered Subsets of Projection Data", IEEE Trans Med Imag, Vol, 13, pp. 601-609, 1994 https://doi.org/10.1109/42.363108
  7. Sheep LA, Vardi Y, "Maximum likelihood reconstruction for emission tomography", IEEE Trans Med Imag, Vol, MI-2, pp, 113-12, 1982
  8. Lai K. Leong, Randall L. Kruger, and Micheal K, O' Connor "A Comparision of the Uniformity Requirements for SPECT Image Reconstruction Usiong FBP and OSEM Techniques" J Nucl Med Technol 2001;29;79-83
  9. F. Nobili et al. "Nuclear Medicine and Biology 28 (2001) 627-632
  10. Walter Koch, MD "Is iterative reconstruction an alternative to filtered backprojection in routine processing of dopamine transporter SPECT studies? J Nucl 2005;46:1804-1811
  11. Jack L. Lancaster, Marty G, Woldorff, Lanwrence M. Parsons, Mirio Liotti, Catarina S. Freitas, Lacy Rainey, Peter V. Kochunov, Dan Nickerson, Shawn A. Mikiten, Peter T. Fox, Human Brain Mapping. 10, 120-131(200) https://doi.org/10.1002/1097-0193(200007)10:3<120::AID-HBM30>3.0.CO;2-8