Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Inhibitory Effects of Ginger and Processed (Beopje) Ginger Extracts on HCl-ethanol Induced Gastritis in Rats

염산-에탄올에 의해 유발된 흰쥐 위염에 대한 생강 및 법제생강 추출물의 억제작용

  • Received : 2012.06.05
  • Accepted : 2012.10.09
  • Published : 2012.11.30
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Abstract

This study examined the protective effects of ginger and processed (Beopje) ginger extracts on gastritis induced by HCl-ethanol in SD-rats. Beopje (or Poje) is a branch of herbal medicines processed using a Korean traditional method to achieve specific pharmacological effects. Gastric lesions were induced in the rats by a treatment of 1 mL of HCl-ethanol (60% ethanol＋150 mM HCl). The rats were divided into seven groups: Normal (1 mL of saline without HCl-ethanol treated group), Control (HCl-ethanol treated group), GL (35 mg/kg of ginger treated group), BGL (35 mg/kg of Beopje ginger treated group), GH (350 mg/kg of ginger treated group), BGH (350 mg/kg of Beopje ginger treated group) and Cimetidine (80 mg/kg of cimetidine treated group). The gastric injury inhibition rate was 40.2% and 64.9% in GL and BGL and 68.4% and 99.6% in GH and BGH respectively, showing significantly lower rates than the control (p<0.05). The level of gastric juice secretion decreased significantly in all ginger administered groups. The pH of the gastric juices of BGH increased and the acidity of BGH and cimetidine decreased significantly (p<0.05) compared to the other groups. Beopje ginger had stronger inhibitory effects on gastritis than ginger without the Beopje process. The protective effect on gastritis by the ginger and Beopje ginger extracts increased in a dose-dependent manner (p<0.05). These results suggest that ginger has inhibitory effects on HCl-ethanol induced gastritis in rats that can be improved through the Beopje process.

본 연구에서는 한의학 이론에 근거한 법제(포제)의 가공처리과정을 거친 생강과 일반생강의 위손상 억제효과를 알아보고자 하였다. Sprague-Dawley계 수컷 흰쥐에 HCl-ethanol로 급성위염을 유도하고, 이에 대한 위손상 억제효과를 검토하였다. 생강과 법제생강을 70% ethanol로 열수 추출 및 농축하여 실험에 사용하였고, 생강과 법제생강 투여군 모두 유의적인 위손상 억제효과가 있는 것으로 나타났다(p<0.05). 생강 저농도와 법제생강 저농도의 위손상 억제율은 40.2%, 64.9%, 생강 고농도와 법제생강 고농도의 위손상 억제율은 68.4%, 99.6%로 법제생강 투여군이 생강 투여군보다 위손상 억제효과가 증가되었다. 특히 법제생강 고농도의 위손상 억제율은 대조약물인 cimetidine의 74.9%보다 높은 99.6%를 나타내었다. 위액분비량은 생강과 법제생강을 투여한 군 모두 유의적으로 감소하였고, 법제생강 투여군의 위액분비량(0.32 mL, 2.69 mL)이 생강 투여군(2.66 mL, 3.23 mL)보다 유의적으로 감소되었다(p<0.05). 위액 pH는 법제생강 고농도가 유의성 있게 증가하였고, 유리산도는 cimetidine과 법제생강 고농도에서 유의성 있게 감소되었다(p<0.05). 생강과 법제생강의 투여 용량의 증가에 따라 위손상 억제효과가 증가하였으며, 특히 법제생강고농도는 대조약물인 cimetidine보다도 높은 위손상 억제효과를 나타내었다. 이상의 결과로 생강은 위손상 억제효과가 있음을 확인하였고, 법제의 가공과정에 의해 생강의 위손상 억제효과가 더 증가되었음을 확인할 수 있었다.

Keywords

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