한국응용과학기술학회지 (Journal of the Korean Applied Science and Technology)

  • 제28권1호
  • /
  • Pages.118-125
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  • 2011
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  • 1225-9098(pISSN)
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  • 2288-1069(eISSN)
한국응용과학기술학회 (The Korean Society of Applied Science and Technology)
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새로운 5-Fluorobenzimidazole 항진균제의 합성과 생물학적 평가

Synthesis and Biological Valutaion of New 5-Fluorobenzimidazole Antifungal Agents

  • 투고 : 2011.02.22
  • 심사 : 2011.03.18
  • 발행 : 2011.03.30
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초록

New type of 5-fluorobenzimidazole derivatives was synthesized through the reaction of 4-fluoro-5-(2,6-dimethylmorpholinyl)-2-aminoaniline with 5-nitro-2-furoic acid and 5-methoxy-3-chlorobenzothiophene-2-carboxylic acid in presence of PPA and treatment of $OH^-$. the resulting substituted 5-fluorobenzimidazole derivatives(6), (7) was characterized by high solubility in common polar organic solvents. We considered 5-fluorobenzimidazole derivatives were useful especially for antifungal drugs. These results are discussed from the viewpoints of the chemical and physical structures of the 5-fluorobenzimidazole derivatives.

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참고문헌

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