Analytical Science and Technology (분석과학)

The Korean Society of Analytical Sciences (한국분석과학회)
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Measurement of optical purity for commercial naproxen by chiral HPLC

키랄 크로마토그래피에 의한 시판되는 나프록센의 광학순도 측정

  • Received : 2011.09.19
  • Accepted : 2011.10.11
  • Published : 2011.10.25
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Abstract

Optical purities of 10 commercialized naproxens prepared from eight Korean drug companies were examined by an optimized chiral HPLC condition. The Chiralcel OD-H column and ChiralHyun-LE(S)-1 column were used as chiral stationary phases and the mixed eluent of hexane/isopropanol/acetic acid as 100:2.85:0.1 was used as a mobile phase for effective enantioseparation. Optical purity values of most samples were higher than 97 percents, only one of them was about 95 percents. The average relative standard deviation of them appeared very small (0.034%).

8개의 제약회사에서 제조되어 현재 시판되고 있는 10개의 나프록센에 대한 광학순도를 최적조건의 키랄 HPLC로 조사하였다. Chiralcel OD-H 칼럼과 ChiralHyun-LE(S)-1 칼럼을 키랄정지상으로 사용하였고, hexane:isopropanol:acetic acid 이 100:2.85:0.1로 혼합된 용액을 전개용매로 사용하였다. 대부분 시료의 광학순도는 97% 이상이었고, 하나는 95% 수준으로 나타났다. 이 값들에 대한 상대표준편차 평균은 0.034%로 매우 작게 나타났다.

Keywords

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