Inhibitory Effect of Eggplant Extract on Adipocyte Differentiation in 3T3-L1 Cells

가지 물추출물의 3T3-L1 지방전구세포 분화 억제효능

  • Lee, Mi-Kyeong (College of Pharmacy, Chungbuk National University) ;
  • Liu, Qing (College of Pharmacy, Chungbuk National University) ;
  • Hwang, Bang-Yeon (College of Pharmacy, Chungbuk National University) ;
  • Kim, Sun-Yeou (Graduate School of East-West Medical Science, Kyung Hee University Global Campus) ;
  • Lee, Jae-Hak (Korea Plant Resource Institute)
  • Received : 2011.04.25
  • Accepted : 2011.05.31
  • Published : 2011.08.31


Abnormal growth of adipocyte characterized by increased cell numbers and differentiation is considered as an major pathological characteristic feature in obesity. Thus, inhibition of mitogenesis of preadipocytes and their differentiation to adipocytes would be beneficial for the prevention and inhibition of obesity. In the present study, we attempted to evaluate anti-adipogenic activity of eggplants (the fruits of Solanum melongena L.) employing preadipocytes cell line, 3T3-L1 as an in vitro assay system. Water extract of eggplants significantly inhibited adipocyte differentiation when treated during adipocyte differentiation process, as assessed by measuring fat accumulation using Oil Red O staining. Eggplant extract, however, showed little effects on fully differentiated adipocytes. Eggplant didn't show significant toxicity up to 500 ${\mu}g$/ml to the 3T3-L1 cells. Further studies with interval treatment demonstrated that eggplant exerted inhibitory activity on adipocyte differentiation via acting on early stage of adipogenesis. Conclusively, eggplants are suggested to be beneficial for the prevention of obesity.



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