References
- Heinz A, Schlagenhauf F. Dopaminergic dysfunction in schizophrenia: salience attribution revisited. Schizophr Bull 2010;36:472-485. https://doi.org/10.1093/schbul/sbq031
- Miuller N, Schwarz MJ. The immunological basis of glutamatergic disturbance in schizophrenia: towards an integrated view. J Neural Transm Suppl 2007:269-280.
- Nanitsos EK, Nguyen KT, St'astny F, Balcar VJ. Glutamatergic hypothesis of schizophrenia: involvement of Na+/K+-dependent glutamate transport. J Biomed Sci 2005;12:975-984. https://doi.org/10.1007/s11373-005-9015-0
- Gonzalez-Burgos G, Hashimoto T, Lewis DA. Alterations of cortical GABA neurons and network oscillations in schizophrenia. Curr Psychiatry Rep 2010;12:335-344. https://doi.org/10.1007/s11920-010-0124-8
- Uhlhaas PJ, Singer W. Abnormal neural oscillations and synchrony in schizophrenia. Nat Rev Neurosci 2010;11:100-113. https://doi.org/10.1038/nrn2774
- McCreary AC, Jones CA. Antipsychotic medication: the potential role of 5-HT (1A) receptor agonism. Curr Pharm Des 2010;16:516-521. https://doi.org/10.2174/138161210790361470
- Geyer MA, Vollenweider FX. Serotonin research: contributions to understanding psychoses. Trends Pharmacol Sci 2008;29:445-453. https://doi.org/10.1016/j.tips.2008.06.006
- Ross RG, Stevens KE, Proctor WR, Leonard S, Kisley MA, Hunter SK, et al. Research review: cholinergic mechanisms, early brain development, and risk for schizophrenia. J Child Psychol Psychiatry 2010;51:535-549. https://doi.org/10.1111/j.1469-7610.2009.02187.x
- Keshavan MS, Tandon R, Boutros NN, Nasrallah HA. Schizophrenia, "just the facts": what we know in 2008 Part 3: neurobiology. Schizophr Res 2008;106:89-107. https://doi.org/10.1016/j.schres.2008.07.020
- Ross CA, Pearlson GD. Schizophrenia, the heteromodal association neocortex and development: potential for a neurogenetic approach. Trends Neurosci 1996;19:171-176. https://doi.org/10.1016/S0166-2236(96)10022-9
- Nasrallah HA. The unintegrated right cerebral hemispheric consciousness as alien intruder: a possible mechanism for Schneiderian delusions in schizophrenia. Compr Psychiatry 1985;26:273-282. https://doi.org/10.1016/0010-440X(85)90072-0
- Crow TJ. Constraints on concepts of pathogenesis. Language and the speciation process as the key to the etiology of schizophrenia. Arch Gen Psychiatry 1995;52:1011-1014; discussion 1019-1024. https://doi.org/10.1001/archpsyc.1995.03950240029006
- Andreasen NC. A unitary model of schizophrenia: Bleuler's "fragmented phrene" as schizencephaly. Arch Gen Psychiatry 1999;56: 781-787. https://doi.org/10.1001/archpsyc.56.9.781
- Williamson P. Are anticorrelated networks in the brain relevant to schizophrenia? Schizophr Bull 2007;33:994-1003. https://doi.org/10.1093/schbul/sbm043
- Weinberger DR. Implications of normal brain development for the pathogenesis of schizophrenia. Arch Gen Psychiatry 1987;44:660-669. https://doi.org/10.1001/archpsyc.1987.01800190080012
- Keshavan MS, Bagwell WW, Haas GL, Sweeney JA, Schooler NR, Pettegrew JW. Changes in caudate volume with neuroleptic treatment. Lancet 1994;344:1434.
- DeLisi LE. Is schizophrenia a lifetime disorder of brain plasticity, growth and aging? Schizophr Res 1997;23:119-129. https://doi.org/10.1016/S0920-9964(96)00079-5
- Lieberman JA, Sheitman BB, Kinon BJ. Neurochemical sensitization in the pathophysiology of schizophrenia: deficits and dysfunction in neuronal regulation and plasticity. Neuropsychopharmacology 1997;17:205-229. https://doi.org/10.1016/S0893-133X(97)00045-6
- Gottesman II, Shields J. A polygenic theory of schizophrenia. Proc Natl Acad Sci U S A 1967;58:199-205. https://doi.org/10.1073/pnas.58.1.199
- Petronis A. The origin of schizophrenia: genetic thesis, epigenetic antithesis, and resolving synthesis. Biol Psychiatry 2004;55:965-970. https://doi.org/10.1016/j.biopsych.2004.02.005
- van Os J, Krabbendam L, Myin-Germeys I, Delespaul P. The schizophrenia envirome. Curr Opin Psychiatry 2005;18:141-145. https://doi.org/10.1097/00001504-200503000-00006
- Ellison-Wright I, Glahn DC, Laird AR, Thelen SM, Bullmore E. The anatomy of first-episode and chronic schizophrenia: an anatomical likelihood estimation meta-analysis. Am J Psychiatry 2008;165: 1015-1023. https://doi.org/10.1176/appi.ajp.2008.07101562
- Seok Jeong B, Kwon JS, Yoon Kim S, Lee C, Youn T, Moon CH, et al. Functional imaging evidence of the relationship between recurrent psychotic episodes and neurodegenerative course in schizophrenia. Psychiatry Res 2005;139:219-228. https://doi.org/10.1016/j.pscychresns.2004.01.008
- Yucel M, Brewer WJ, Harrison BJ, Fornito A, O'Keefe GJ, Olver J, et al. Anterior cingulate activation in antipsychotic-naïve first-episode schizophrenia. Acta Psychiatr Scand 2007;115:155-158. https://doi.org/10.1111/j.1600-0447.2006.00902.x
- van Veelen NM, Vink M, Ramsey NF, Kahn RS. Left dorsolateral prefrontal cortex dysfunction in medication-naive schizophrenia. Schizophr Res 2010;123:22-29. https://doi.org/10.1016/j.schres.2010.07.004
- Smieskova R, Fusar-Poli P, Allen P, Bendfeldt K, Stieglitz RD, Drewe J, et al. Neuroimaging predictors of transition to psychosis--a systematic review and meta-analysis. Neurosci Biobehav Rev 2010; 34:1207-1222. https://doi.org/10.1016/j.neubiorev.2010.01.016
- Pantelis C, Velakoulis D, McGorry PD, Wood SJ, Suckling J, Phillips LJ, et al. Neuroanatomical abnormalities before and after onset of psychosis: a cross-sectional and longitudinal MRI comparison. Lancet 2003;361:281-288. https://doi.org/10.1016/S0140-6736(03)12323-9
- Borgwardt SJ, Riecher-Rossler A, Dazzan P, Chitnis X, Aston J, Drewe M, et al. Regional gray matter volume abnormalities in the at risk mental state. Biol Psychiatry 2007;61:1148-1156. https://doi.org/10.1016/j.biopsych.2006.08.009
- Koutsouleris N, Meisenzahl EM, Davatzikos C, Bottlender R, Frodl T, Scheuerecker J, et al. Use of neuroanatomical pattern classification to identify subjects in at-risk mental states of psychosis and predict disease transition. Arch Gen Psychiatry 2009;66:700-712. https://doi.org/10.1001/archgenpsychiatry.2009.62
- Borgwardt SJ, McGuire PK, Aston J, Gschwandtner U, Pfluger MO, Stieglitz RD, et al. Reductions in frontal, temporal and parietal volume associated with the onset of psychosis. Schizophr Res 2008;106: 108-114. https://doi.org/10.1016/j.schres.2008.08.007
- Job DE, Whalley HC, McConnell S, Glabus M, Johnstone EC, Lawrie SM. Voxel-based morphometry of grey matter densities in subjects at high risk of schizophrenia. Schizophr Res 2003;64:1-13. https://doi.org/10.1016/S0920-9964(03)00158-0
- Sun D, Phillips L, Velakoulis D, Yung A, McGorry PD, Wood SJ, et al. Progressive brain structural changes mapped as psychosis develops in 'at risk' individuals. Schizophr Res 2009;108:85-92. https://doi.org/10.1016/j.schres.2008.11.026
- Harris JM, Whalley H, Yates S, Miller P, Johnstone EC, Lawrie SM. Abnormal cortical folding in high-risk individuals: a predictor of the development of schizophrenia? Biol Psychiatry 2004;56:182-189. https://doi.org/10.1016/j.biopsych.2004.04.007
- Velakoulis D, Wood SJ, Wong MT, McGorry PD, Yung A, Phillips L, et al. Hippocampal and amygdala volumes according to psychosis stage and diagnosis: a magnetic resonance imaging study of chronic schizophrenia, first-episode psychosis, and ultra-high-risk individuals. Arch Gen Psychiatry 2006;63:139-149. https://doi.org/10.1001/archpsyc.63.2.139
- Takahashi T, Wood SJ, Yung AR, Soulsby B, McGorry PD, Suzuki M, et al. Progressive gray matter reduction of the superior temporal gyrus during transition to psychosis. Arch Gen Psychiatry 2009; 66:366-376. https://doi.org/10.1001/archgenpsychiatry.2009.12
- Takahashi T, Wood SJ, Yung AR, Phillips LJ, Soulsby B, McGorry PD, et al. Insular cortex gray matter changes in individuals at ultrahigh- risk of developing psychosis. Schizophr Res 2009;111:94-102. https://doi.org/10.1016/j.schres.2009.03.024
- Buehlmann E, Berger GE, Aston J, Gschwandtner U, Pflueger MO, Borgwardt SJ, et al. Hippocampus abnormalities in at risk mental states for psychosis? A cross-sectional high resolution region of interest magnetic resonance imaging study. J Psychiatr Res 2010;44: 447-453. https://doi.org/10.1016/j.jpsychires.2009.10.008
- Suddath RL, Christison GW, Torrey EF, Casanova MF, Weinberger DR. Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia. N Engl J Med 1990;322:789-794. https://doi.org/10.1056/NEJM199003223221201
- Pantelis C, Yucel M, Bora E, Fornito A, Testa R, Brewer WJ, et al. Neurobiological markers of illness onset in psychosis and schizophrenia: The search for a moving target. Neuropsychol Rev 2009;19: 385-398. https://doi.org/10.1007/s11065-009-9114-1
- Whalley HC, Simonotto E, Moorhead W, McIntosh A, Marshall I, Ebmeier KP, et al. Functional imaging as a predictor of schizophrenia. Biol Psychiatry 2006;60:454-462. https://doi.org/10.1016/j.biopsych.2005.11.013
- Whalley HC, Harris JC, Lawrie SM. The neurobiological underpinnings of risk and conversion in relatives of patients with schizophrenia. Int Rev Psychiatry 2007;19:383-397. https://doi.org/10.1080/09540260701496869
- Marjoram D, Job DE, Whalley HC, Gountouna VE, McIntosh AM, Simonotto E, et al. A visual joke fMRI investigation into Theory of Mind and enhanced risk of schizophrenia. Neuroimage 2006;31: 1850-1858. https://doi.org/10.1016/j.neuroimage.2006.02.011
- Broome MR, Matthiasson P, Fusar-Poli P, Woolley JB, Johns LC, Tabraham P, et al. Neural correlates of executive function and working memory in the 'at-risk mental state'. Br J Psychiatry 2009;194: 25-33. https://doi.org/10.1192/bjp.bp.107.046789
- Benetti S, Mechelli A, Picchioni M, Broome M, Williams S, Mc- Guire P. Functional integration between the posterior hippocampus and prefrontal cortex is impaired in both first episode schizophrenia and the at risk mental state. Brain 2009;132:2426-2436. https://doi.org/10.1093/brain/awp098
- Crossley NA, Mechelli A, Fusar-Poli P, Broome MR, Matthiasson P, Johns LC, et al. Superior temporal lobe dysfunction and frontotemporal dysconnectivity in subjects at risk of psychosis and in firstepisode psychosis. Hum Brain Mapp 2009;30:4129-4137. https://doi.org/10.1002/hbm.20834
- Fusar-Poli P, Perez J, Broome M, Borgwardt S, Placentino A, Caverzasi E, et al. Neurofunctional correlates of vulnerability to psychosis: a systematic review and meta-analysis. Neurosci Biobehav Rev 2007;31:465-484. https://doi.org/10.1016/j.neubiorev.2006.11.006
- Conrad AJ, Abebe T, Austin R, Forsythe S, Scheibel AB. Hippocampal pyramidal cell disarray in schizophrenia as a bilateral phenomenon. Arch Gen Psychiatry 1991;48:413-417. https://doi.org/10.1001/archpsyc.1991.01810290025003
- Jeong B, Wible CG, Hashimoto R, Kubicki M. Functional and anatomical connectivity abnormalities in left inferior frontal gyrus in schizophrenia. Hum Brain Mapp 2009;30:4138-4151. https://doi.org/10.1002/hbm.20835
- Henseler I, Falkai P, Gruber O. Disturbed functional connectivity within brain networks subserving domain-specific subcomponents of working memory in schizophrenia: relation to performance and clinical symptoms. J Psychiatr Res 2010;44:364-372. https://doi.org/10.1016/j.jpsychires.2009.09.003
- van den Heuvel MP, Mandl RC, Stam CJ, Kahn RS, Hulshoff Pol HE. Aberrant frontal and temporal complex network structure in schizophrenia: a graph theoretical analysis. J Neurosci 2010;30: 15915-15926. https://doi.org/10.1523/JNEUROSCI.2874-10.2010
- Alexander-Bloch AF, Gogtay N, Meunier D, Birn R, Clasen L, Lalonde F, et al. Disrupted modularity and local connectivity of brain functional networks in childhood-onset schizophrenia. Front Syst Neurosci 2010;4:147.
- Lynall ME, Bassett DS, Kerwin R, McKenna PJ, Kitzbichler M, Muller U, et al. Functional connectivity and brain networks in schizophrenia. J Neurosci 2010;30:9477-9487. https://doi.org/10.1523/JNEUROSCI.0333-10.2010
- Calhoun VD, Eichele T, Pearlson G. Functional brain networks in schizophrenia: a review. Front Hum Neurosci 2009;3:17.
- Peters BD, Blaas J, de Haan L. Diffusion tensor imaging in the early phase of schizophrenia: what have we learned? J Psychiatr Res 2010; 44:993-1004. https://doi.org/10.1016/j.jpsychires.2010.05.003
- Davis KL, Stewart DG, Friedman JI, Buchsbaum M, Harvey PD, Hof PR, et al. White matter changes in schizophrenia: evidence for myelin-related dysfunction. Arch Gen Psychiatry 2003;60:443-456. https://doi.org/10.1001/archpsyc.60.5.443
- Segal D, Koschnick JR, Slegers LH, Hof PR. Oligodendrocyte pathophysiology: a new view of schizophrenia. Int J Neuropsychopharmacol 2007;10:503-511. https://doi.org/10.1017/S146114570600722X
- Tkachev D, Mimmack ML, Ryan MM, Wayland M, Freeman T, Jones PB, et al. Oligodendrocyte dysfunction in schizophrenia and bipolar disorder. Lancet 2003;362:798-805. https://doi.org/10.1016/S0140-6736(03)14289-4
- Konrad A, Winterer G. Disturbed structural connectivity in schizophrenia primary factor in pathology or epiphenomenon? Schizophr Bull 2008;34:72-92.
- Hyde TM, Ziegler JC, Weinberger DR. Psychiatric disturbances in metachromatic leukodystrophy. Insights into the neurobiology of psychosis. Arch Neurol 1992;49:401-406. https://doi.org/10.1001/archneur.1992.00530280095028
- Bartzokis G, Lu PH, Stewart SB, Oluwadara B, Lucas AJ, Pantages J, et al. In vivo evidence of differential impact of typical and atypical antipsychotics on intracortical myelin in adults with schizophrenia. Schizophr Res 2009;113:322-331. https://doi.org/10.1016/j.schres.2009.06.014
- Bullmore ET, Frangou S, Murray RM. The dysplastic net hypothesis: an integration of developmental and dysconnectivity theories of schizophrenia. Schizophr Res 1997;28:143-156. https://doi.org/10.1016/S0920-9964(97)00114-X
- Beaulieu C. The basis of anisotropic water diffusion in the nervous system - a technical review. NMR Biomed 2002;15:435-455. https://doi.org/10.1002/nbm.782
- Gulani V, Webb AG, Duncan ID, Lauterbur PC. Apparent diffusion tensor measurements in myelin-deficient rat spinal cords. Magn Reson Med 2001;45:191-195. https://doi.org/10.1002/1522-2594(200102)45:2<191::AID-MRM1025>3.0.CO;2-9
- Ono J, Harada K, Takahashi M, Maeda M, Ikenaka K, Sakurai K, et al. Differentiation between dysmyelination and demyelination using magnetic resonance diffusional anisotropy. Brain Res 1995;671: 141-148. https://doi.org/10.1016/0006-8993(94)01335-F
- Kawashima T, Nakamura M, Bouix S, Kubicki M, Salisbury DF, Westin CF, et al. Uncinate fasciculus abnormalities in recent onset schizophrenia and affective psychosis: a diffusion tensor imaging study. Schizophr Res 2009;110:119-126. https://doi.org/10.1016/j.schres.2009.01.014
- Fitzsimmons J, Kubicki M, Smith K, Bushell G, Estepar RS, Westin CF, et al. Diffusion tractography of the fornix in schizophrenia. Schizophr Res 2009;107:39-46. https://doi.org/10.1016/j.schres.2008.10.022
- Kubicki M, Park H, Westin CF, Nestor PG, Mulkern RV, Maier SE, et al. DTI and MTR abnormalities in schizophrenia: analysis of white matter integrity. Neuroimage 2005;26:1109-1118. https://doi.org/10.1016/j.neuroimage.2005.03.026
- Ardekani BA, Tabesh A, Sevy S, Robinson DG, Bilder RM, Szeszko PR. Diffusion tensor imaging reliably differentiates patients with schizophrenia from healthy volunteers. Hum Brain Mapp 2011;32: 1-9. https://doi.org/10.1002/hbm.20995
- Cheung V, Cheung C, McAlonan GM, Deng Y, Wong JG, Yip L, et al. A diffusion tensor imaging study of structural dysconnectivity in never-medicated, first-episode schizophrenia. Psychol Med 2008; 38:877-885.
- Gasparotti R, Valsecchi P, Carletti F, Galluzzo A, Liserre R, Cesana B, et al. Reduced fractional anisotropy of corpus callosum in firstcontact, antipsychotic drug-naive patients with schizophrenia. Schizophr Res 2009;108:41-48. https://doi.org/10.1016/j.schres.2008.11.015
- Karlsgodt KH, van Erp TG, Poldrack RA, Bearden CE, Nuechterlein KH, Cannon TD. Diffusion tensor imaging of the superior longitudinal fasciculus and working memory in recent-onset schizophrenia. Biol Psychiatry 2008;63:512-518. https://doi.org/10.1016/j.biopsych.2007.06.017
- Szeszko PR, Robinson DG, Sevy S, Kumra S, Rupp CI, Betensky JD, et al. Anterior cingulate grey-matter deficits and cannabis use in first-episode schizophrenia. Br J Psychiatry 2007;190:230-236. https://doi.org/10.1192/bjp.bp.106.024521
- Peters BD, de Haan L, Dekker N, Blaas J, Becker HE, Dingemans PM, et al. White matter fibertracking in first-episode schizophrenia, schizoaffective patients and subjects at ultra-high risk of psychosis. Neuropsychobiology 2008;58:19-28. https://doi.org/10.1159/000154476
- Peters BD, Dingemans PM, Dekker N, Blaas J, Akkerman E, van Amelsvoort TA, et al. White matter connectivity and psychosis in ultra-high-risk subjects: a diffusion tensor fiber tracking study. Psychiatry Res 2010;181:44-50. https://doi.org/10.1016/j.pscychresns.2009.10.008
- Peters BD, Schmitz N, Dingemans PM, van Amelsvoort TA, Linszen DH, de Haan L, et al. Preliminary evidence for reduced frontal white matter integrity in subjects at ultra-high-risk for psychosis. Schizophr Res 2009;111:192-193. https://doi.org/10.1016/j.schres.2009.03.018
- Bloemen OJ, de Koning MB, Schmitz N, Nieman DH, Becker HE, de Haan L, et al. White-matter markers for psychosis in a prospective ultra-high-risk cohort. Psychol Med 2010;40:1297-1304. https://doi.org/10.1017/S0033291709991711
- Munoz Maniega S, Lymer GK, Bastin ME, Marjoram D, Job DE, Moorhead TW, et al. A diffusion tensor MRI study of white matter integrity in subjects at high genetic risk of schizophrenia. Schizophr Res 2008;106:132-139. https://doi.org/10.1016/j.schres.2008.09.016
- Hoptman MJ, Nierenberg J, Bertisch HC, Catalano D, Ardekani BA, Branch CA, et al. A DTI study of white matter microstructure in individuals at high genetic risk for schizophrenia. Schizophr Res 2008;106:115-124. https://doi.org/10.1016/j.schres.2008.07.023
- Camchong J, Lim KO, Sponheim SR, Macdonald AW. Frontal white matter integrity as an endophenotype for schizophrenia: diffusion tensor imaging in monozygotic twins and patients' nonpsychotic relatives. Front Hum Neurosci 2009;3:35.
- Bora E, Fornito A, Radua J, Walterfang M, Seal M, Wood SJ, et al. Neuroanatomical abnormalities in schizophrenia: a multimodal voxelwise meta-analysis and meta-regression analysis. Schizophr Res 2011;127:46-57. https://doi.org/10.1016/j.schres.2010.12.020
- Murakami M, Takao H, Abe O, Yamasue H, Sasaki H, Gonoi W, et al. Cortical thickness, gray matter volume, and white matter anisotropy and diffusivity in schizophrenia. Neuroradiology 2011.
- Whitford TJ, Kubicki M, Ghorashi S, Schneiderman JS, Hawley KJ, McCarley RW, et al. Predicting inter-hemispheric transfer time from the diffusion properties of the corpus callosum in healthy individuals and schizophrenia patients: a combined ERP and DTI study. Neuroimage 2011;54:2318-2329. https://doi.org/10.1016/j.neuroimage.2010.10.048
- Weiss AP, Ellis CB, Roffman JL, Stufflebeam S, Hamalainen MS, Duff M, et al. Aberrant frontoparietal function during recognition memory in schizophrenia: a multimodal neuroimaging investigation. J Neurosci 2009;29:11347-11359. https://doi.org/10.1523/JNEUROSCI.0617-09.2009
- Kahler AK, Djurovic S, Rimol LM, Brown AA, Athanasiu L, Jonsson EG, et al. Candidate gene analysis of the human natural killer-1 carbohydrate pathway and perineuronal nets in schizophrenia: B3GAT2 is associated with disease risk and cortical surface area. Biol Psychiatry 2011;69:90-96. https://doi.org/10.1016/j.biopsych.2010.07.035
- Habets P, Marcelis M, Gronenschild E, Drukker M, van Os J; Genetic Risk and Outcome of Psychosis (G.R.O.U.P). Reduced cortical thickness as an outcome of differential sensitivity to environmental risks in schizophrenia. Biol Psychiatry 2011;69:487-494. https://doi.org/10.1016/j.biopsych.2010.08.010
- Nicodemus KK, Law AJ, Radulescu E, Luna A, Kolachana B, Vakkalanka R, et al. Biological validation of increased schizophrenia risk with NRG1, ERBB4, and AKT1 epistasis via functional neuroimaging in healthy controls. Arch Gen Psychiatry 2010;67:991-1001. https://doi.org/10.1001/archgenpsychiatry.2010.117
- Nicodemus KK, Callicott JH, Higier RG, Luna A, Nixon DC, Lipska BK, et al. Evidence of statistical epistasis between DISC1, CIT and NDEL1 impacting risk for schizophrenia: biological validation with functional neuroimaging. Hum Genet 2010;127:441-452. https://doi.org/10.1007/s00439-009-0782-y
- Tregellas JR, Tanabe J, Rojas DC, Shatti S, Olincy A, Johnson L, et al. Effects of an alpha 7-nicotinic agonist on default network activity in schizophrenia. Biol Psychiatry 2011;69:7-11. https://doi.org/10.1016/j.biopsych.2010.07.004
- Esslinger C, Kirsch P, Haddad L, Mier D, Sauer C, Erk S, et al. Cognitive state and connectivity effects of the genome-wide significant psychosis variant in ZNF804A. Neuroimage 2011;54:2514-2523. https://doi.org/10.1016/j.neuroimage.2010.10.012
- Walter H, Schnell K, Erk S, Arnold C, Kirsch P, Esslinger C, et al. Effects of a genome-wide supported psychosis risk variant on neural activation during a theory-of-mind task. Mol Psychiatry 2011; 16:462-470. https://doi.org/10.1038/mp.2010.18