Korean Journal of Biological Psychiatry (생물정신의학)

The Korean Society of Biological Psychiatry (대한생물정신의학회)
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An Association Study of the Dopamine D2 Receptor Taq1A Polymorphism and Temperament in Korean Pathological Gamblers

한국인 병적 도박 환자에서 기질특성과 도파민 D2 수용체 Taq1A 다형성의 연합 연구

  • Kwon, Yong-Seok (Department of Psychiatry, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine) ;
  • Lim, Se-Won (Department of Psychiatry, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine) ;
  • Shin, Young-Chul (Department of Psychiatry, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine)
  • 권용석 (성균관대학교 의과대학 강북삼성병원 정신과학교실) ;
  • 임세원 (성균관대학교 의과대학 강북삼성병원 정신과학교실) ;
  • 신영철 (성균관대학교 의과대학 강북삼성병원 정신과학교실)
  • Received : 2011.02.11
  • Accepted : 2011.04.18
  • Published : 2011.08.31
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Abstract

Objective It has been suggested that the dopamine D2 receptor gene (DRD2) is associated with pathological gambling (PG). We investigated the association of the DRD2 Taq1A polymorphism and the temperament in PG using Cloninger's temperament and characteristic inventory (TCI). Methods 104 PG patients and 114 control subjects were recruited. Tests for DRD2 Taq1A polymorphism were conducted in both PG patients and controls. PG patients were requested to complete the TCI. Results There were no significant differences in frequencies of the genotype (${\chi}^2$ = 0.77, p = 0.681), allele (${\chi}^2$ = 0.52, p = 0.469), and allele (A1) carrier (${\chi}^2$ = 0.15, p = 0.695) between the PG patients and the control group. When we compared the TCI profile in the PG patients according to genotypes, there were significant differences in harm-avoidance (HA, p = 0.033), and self-directedness (SD, p = 0.012) among genotypes. These difference were more evident between A1 allele carriers and non-carriers (HA, p = 0.009 and SD, p = 0.004). Conclusion Present results suggest Taq1A polymorphism may not play an important role in the susceptibility to pathological gambling in our population. However, Taq1A polymorphism might be associated with some temperament in Korean PG patients.

Keywords

References

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