Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Antiosteoporotic Effects of Polygoni Multiflori Radix (PMR) in Ovariectomized (OVX)-Induced Osteoporosis ddY Mice

하수오 물 추출물이 마우스 골다공증에 미치는 영향

  • 도윤정 (농촌진흥청 국립축산과학원) ;
  • 구세광 (대구한의대학교 한의과대학) ;
  • 김홍태 (부산광역시 보건환경연구원) ;
  • 오태호 (경북대학교 수의과대학) ;
  • 조영무 (농촌진흥청 국립축산과학원) ;
  • 김성우 (농촌진흥청 국립축산과학원) ;
  • 유일선 (농촌진흥청 국립축산과학원) ;
  • 이근우 (경북대학교 수의과대학)
  • Accepted : 2011.08.27
  • Published : 2011.08.30
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Abstract

Polygoni Multiflori Radix (PMR), a dried root tuber of Polygonum multiflorum Thunberg with bioactivities in bone metabolism is one of the most famous tonic traditional medicines. To observe in vivo anti-osteoporotic efficacy of PMR extracts, we orally administered once a day for 28 days (Qd ${\times}$ 28) to bilateral ovariectomized (OVX)-induced osteoporosis ddY mice after 1 week of recovery periods at 125, 250 and 500 mg/kg (of body weight). A positive control drug, Alendronate (FOSA) 10 mg/kg-dosing group was added. As results of OVX-induced osteoporotic process, estrogen-deficient osteoporotic changes were also dramatically decreased in all PMR extracts-dosing groups. Especially middle dosage of PMR extracts, 250 mg/kg constantly and significantly (p < 0.01 or p < 0.05) inhibited the loss of bone strength and bone quality. Based on the results, it was concluded that PMR extracts (125, 250 or 500 mg/kg; orally dosing) has relatively good favorable effect to prevention and/or treatment of OVX-induced osteoporosis. Therefore, although the efficacy was slighter than that of Alendronate on the inhibition of bone loss, it is expected that PMR extracts will be promising as a new anti-osteoporotic agents for prevent the fracture induced in osteoporotic patients because natural herbal medicine origin PMR extracts will be dose not show serious side effects especially the problem in upper alimentary irritation by bisphosphonate and hypercalcaemia of parathyroid hormone analogs.

Keywords

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