Journal of Pharmacopuncture (대한약침학회지)

KOREAN PHARMACOPUNCTURE INSTITUTE (대한약침학회)
권호 표지
DOI QR코드

DOI QR Code

Effect of Artemisia capillaries on Gene Expression of Lipid Metabolism in Rat

인진호(茵蔯蒿)가 지질대사에 관여하는 유전자의 발현에 미치는 영향

  • Jang, Woo-Seok (Department of Internal Medicine, Daegu-Haany University College of Oriental Medicine)
  • 장우석 (대구한의대학교 한의과대학 내과학교실)
  • Received : 2011.07.18
  • Accepted : 2011.08.22
  • Published : 2011.09.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives : The purpose of this study is to evaluate the effect of Artemisia capillaries on gene expression of lipid metabolism in rats. Methods : The author performed several experimental items to analyze the total cholesterol and triglyceride in liver tissue, the gene expressions of CYP7A1 and HMG-CoA reductase. Results : 1. In Artemisia capillaries group, the levels of total cholesterol in liver tissue were significantly decreased. 2. In Artemisia capillaries group, the ratios of CYP7A1, HMG-CoA reductase were as same as the normal group. Conclusions : From the above results, Artemisia capillaries can be used to treat hyperlipidemia.

Keywords

References

  1. Lee JT, Lee BR, Yang GY, Lee H, Yim YK. A Study on the Effect of Herbal-acupuncture with Artemisiae Carpillaris Herba at GB34 on Hyperlipidemia in Rat. Journal of Meridian & Acupoint. 2010;27(1):107,118.
  2. Park JY, Song CH. The Effect of Bupleuri Radix Herbal-acupuncture at GB34(Yangneungcheon) on Hyperlipidemia in Rats. Korean Journal of Acupuncture. 2010;27(2):121,133.
  3. An GH, Lee H. The Effect of Cnidii Rhizoma Herbal-acupuncture at GB34(Yangneungcheon) on Hyperlipidemia in Rats. The Journal of Korean Acupuncture & Moxibustion. 2010;27(4):138,143.
  4. Choi JS, Yim YK, Lee BR, Yang GY, Kim JK. The Effect of Achyranthis Radix Herbalacupuncture on Hyperlipidemia in Rats. Korean Journal of Acupuncture. 2010;27(3):25-6.
  5. Ham IH, Jung SW, Lee KJ, Park KH, Choi HY. Effect of the aerial part of Artemisia capillaris and A. iwayomogi on the Hyperlipidemia of Rats induced by Triton WR-1339. Kor. J. Herbology. 2005;20(1):46.
  6. Youh EJ, Seo BK, Huang B, Kim JI, Kang SK. Artemisia capillaries Herbal Acupuncture Improves Metabolic Abnormalities in High Fat Diet-induced Obese ICR Mice. The Journal of Korean Acupuncture & Moxibustion. 2011;28(1):1-12.
  7. Song WG, Kang JH, Lee H. The Effect of Puerariae Radix Herbal-acupuncture at GB34(Yangneungcheon) on Hyperlipidemia in Rats. The Journal of Korean Acupuncture & Moxibustion. 2009;26(4):80,86.
  8. Lee SH, Lee H. A Study on the Effect of Herbal-acupuncture with Schizandrae Fructus Solution on Hyperlipidemia in Rats Induced by High Fat Diet. The Journal of Korean Acupuncture & Moxibustion. 2011;28(2):149.
  9. An YS, Ahn TW, Kang HJ, Lee YH, Yim YK. The Effect of Herbal-acupuncture with Moutan Cortex Radix Extract. Journal of Meridian & Acupoint. 2009;26(1):101.
  10. Johnston TP. Poloxamer-407 as a general lipase inhibitor: its implications in lipid metabolism and atheroma formation in C57BL/6 mice. J Pharm Pharmacol. 2010;62(12):1807-12. https://doi.org/10.1111/j.2042-7158.2010.01138.x
  11. Cheon WK, Lim KW. Effects of High-fat Diet Feeding on HMG-CoA Reductase mRNA Levels of Skeletal Muscle in Rats. The Korean Journal of Exercise Nutrition. 2010;14(3):145-6,148.
  12. Pfizer 2008 Annual Report. Pfizer. http://media.pfizer.com/files/annualreport/2008/annual/review2008.pdf.
  13. Bertram G. Katzung. BASIC & CLINICAL PHARMACOLOGY. Seoul:KMS. 2008:589,593.
  14. Yang JL, Lee HJ, Kim YH. Effect of Hormones and Short Chain Fatty Acids on CYP7A1 Gene Expression in HepG2 Cell. J Korean Soc Food Sci Nutr. 2005;34(5):537. https://doi.org/10.3746/jkfn.2005.34.5.573
  15. Kim SC, Seo BI. Bonchojibseong. Seoul:Tree and earth. 2000:368-70.
  16. Suagee JK, Corl BA, Crisman MV, Wearn JG, McCutcheon LJ, Geor RJ. De novo fatty acid synthesis and NADPH generation in equine adipose and liver tissue. Comp Biochem Physiol B Biochem Mol Biol. 2010;155(3):322-6. https://doi.org/10.1016/j.cbpb.2009.11.019