Annals of Clinical Neurophysiology

The Korean Society of Clinical Neurophysiology (대한임상신경생리학회)
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Periodic Lateralized Epileptiform Discharges Are lctal Phenomena, and Need an Antiepileptic Treatment

주기편측간질모양방전은 발작현상으로서 항경련제 치료가 필요하다

  • Kim, Jae-Moon (Department of Neurology, Chungnam National University Hospital)
  • 김재문 (충남대학교병원 신경과)
  • Received : 2011.05.05
  • Accepted : 2011.05.12
  • Published : 2011.06.30
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Abstract

Periodic lateralized epileptiform discharges (PLEDs) had been debated whether it is ictal or non-ictal phenomenon. As most of PLEDs occur in patients with acute structural lesions, some epileptologists prefer PLEDS as a non-ictal phenomenon, rather an obscure epiphenomenon of etiological diseases. But, almost half of the patients with PLEDs do not have acute structural lesions in the brain and metabolic disorders or old CNS lesions may cause PLEDs and even more, no brain lesion was identified in some patients. There are many data supporting PLEDs as ictal phenomena. Occurrence of PLEDs usually accompanied by decreased mentality and is improved as PLEDs disappeared. Current SPECT study showed marked hyperperfusion in the lesion side of PLEDs, that is striking evidence of PLEDs as ictal phenomena. Also careful review of EEG with PLEDs revealed it is a dynamic process rather than a static state. Despite of these evidences, as PLEDs are an end-stage of animal status epilepticus models, it may be a transition of ictal to interictal state.

Keywords

References

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