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The Korean Society for Biotechnology and Bioengineering (한국생물공학회)
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Mal-differentiation of Stem Cells: Cancer and Ageing

줄기세포의 분화 결손으로 인한 노화와 암화

  • Lee, Mi-Ok (College of Natural Sciences, Dept. of Life Sciences, Sogang University) ;
  • Cha, Hyuk-Jin (College of Natural Sciences, Dept. of Life Sciences, Sogang University)
  • 이미옥 (서강대학교 자연과학대학 생명과학과) ;
  • 차혁진 (서강대학교 자연과학대학 생명과학과)
  • Received : 2011.02.21
  • Accepted : 2011.05.21
  • Published : 2011.06.30
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Abstract

Adult stem cells, which have characteristic of self-renewal and multipotency, are specialized cell types, responsible for the tissue regeneration of the damaged tissue. Recent studies suggest that stem cells senescence (or stem cells' ageing) is closely associated with the variety of ageing-related phenotypes such as tissue atrophy, degenerative diseases and onset of cancers. During ageing, declining of stem cells function and subsequently occurring mal-differentiation of stem cells would be important to understand the biological process of development of ageing-related phenotypes such as tissue degenerations and cancers. This review focuses on the DNA damage stress as a cause of senescence of stem cells and their mal differentiation, which is closely link to defect of regeneration potentials and neoplastic transformation. Understanding of molecular mechanisms governingsuch events is likely to have important implications for developing novel avenues for balancing tissue homeostasis longer period of time, further leading to 'Healthy ageing'.

Keywords

References

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