Journal of the Korean Society of Radiology (한국방사선학회논문지)

The Korean Society of Radiology (한국방사선학회)
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Evaluation of Usefulness of SPIO (Superparamagnetic iron oxide) Contrast Agent in MRCP (Magnetic resonance cholangiopancreatography)

자기공명 담도췌장조영술에서의 SPIO 조영제의 유용성 평가

  • Hong, In-Sik (Department of Computer Science and Soonchunhyang University) ;
  • Lee, Hae-Kak (Department of Computer Science and Soonchunhyang University) ;
  • Cho, Jae-Hwan (Department of Radiological Science, Gyeonesan University College) ;
  • Kim, Hyeon-Ju (Department of Radiology, Soonchunhyang University. Hospital) ;
  • Jang, Hyun-Cheol (Department of Radiology, Soonchunhyang University. Hospital) ;
  • Park, Cheol-Soo (Department of Radiological Science, Hanlym College) ;
  • Lee, Sun-Yeob (Department of Radiological Science, Hanlym College) ;
  • Goo, Eun-Hoe (Department of Radiology, Seoul Nationnal University Hospital) ;
  • Dong, Kyung-Rae (Department of Radiological Technology, Gwangju Health College University, Department of Radiological Technology) ;
  • Cho, Moo-Seong (Department of Radiological Science, Gyeonesan University College)
  • 홍인식 (순천향대학교 컴퓨터공학과) ;
  • 이해각 (순천향대학교 컴퓨터공학과) ;
  • 조재환 (경산1대학 방사선과) ;
  • 김현주 (순천향대학교 부천병원 영상의학과) ;
  • 장현철 (순천향대학교 부천병원 영상의학과) ;
  • 박철수 (한림성심대학 방사선과) ;
  • 이선엽 (한림성심대학 방사선과) ;
  • 구은회 (서울대학교병원 영상의학과) ;
  • 동경래 (광주보건대학) ;
  • 조무성 (경산1대학 방사선과)
  • Received : 2011.04.18
  • Accepted : 2011.06.14
  • Published : 2011.06.30
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Abstract

The purpose of this study was to examine the usefulness of SPIO contrast agent in Magnetic Resonance Cholangiopancreatography (MRCP) by performing a quantitative comparative analysis in patients undergoing MRCP for gallbladder stones with and without oral injection of SPIO (Superparamagnetic iron oxide) contrast agent. The subjects were 36 patients undergoing MRCP for suspected gallbladder stones between January 2009 and February 2010 and they were divided into halves to compare the two groups of with and without SPIO agent. For each subject in both the injected and non-injected group, T2-weighted images on a 1.5T MR scanner were obtained, using both the breath-holding and respiratory-triggered methods, respectively. The following regions were measured; for breath-hold T2-weighted images, the measurement regions were located at the central part of the gallbladder, and the areas 15 mm away from its center, toward the front and back, respectively, which were chosen to include surrounding tissues, while for respiratory-triggered T2-weighted images, at the central part of the gallbladder, and segment 5 and 6 of liver. In a quantitative analysis, average signal to noise ratio (SNR) in each of regions of interest (ROI) for each group were calculated and then average contrast to noise ratio (CNR) in each of ROI were obtained by using the SNR in the gallbladder as the basis to compare and analyze the values between the two groups. The CNR were higher for the injected group in those regions.

담낭 결석 환자 중 MRCP를 시행한 환자를 대상으로 SPIO 제제의 조영제를 경구 주입 전, 후를 정량적으로 비교 분석하여 그 유용성을 알아보고자 하였다. 2009년 01월부터 2010년 02월까지 담석증을 보이는 환자 36명을 대상으로 SPIO를 경구 투입한 그룹과 투입하지 않은 그룹으로 나누어 1.5T MR scanner를 사용하여 호흡 정지 기법과 호흡 유발 기법을 이용한 T2강조 영상을 획득 하였다. 측정 부위는 호흡 정지 기법을 이용한 T2강조 영상에서는 담낭의 중앙 부위와 주위 조직의 측정을 위해 담낭 중앙을 기준으로 전, 후로 각각 15mm 떨어진 부위에 위치시켰으며 호흡 유발 기법을 이용한 T2강조 영상에서는 담낭의 중앙 부위와 간의 5,6 구역에 위치시켰다. 실험에 대한 정량적 분석방법으로 두 그룹에서 관심영역의 신호대 잡음비를 구하고 평균화 하였으며 담낭의 신호대 잡음비를 기준으로 각각 관심영역의 대조도대 잡음비를 구하고 평균화 하여 두 그룹 간에 수치를 비교 분석하였다. 두 그룹에서의 대조도대 잡음비는 투입한 그룹에서 높은 대조도대 잡음비를 보였다.

Keywords

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