Parasites, Hosts and Diseases

  • 제49권2호
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  • Pages.109-114
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  • 2011
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  • 2982-5164(pISSN)
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  • 1738-0006(eISSN)
대한기생충학·열대의학회 (The Korea Society for Parasitology and Tropical Medicine)
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Pro-inflammatory Cytokine Expression of Spleen Dendritic Cells in Mouse Toxoplasmosis

  • Nam, Ho-Woo (Department of Parasitology, College of Medicine, Catholic University of Korea) ;
  • Ahn, Hye-Jin (Department of Parasitology, College of Medicine, Catholic University of Korea) ;
  • Yang, Hyun-Jong (Department of Parasitology, School of Medicine, Ewha Womans University)
  • 투고 : 2011.03.01
  • 심사 : 2011.05.10
  • 발행 : 2011.06.30
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초록

Dendritic cells have been known as a member of strong innate immune cells against infectious organelles. In this study, we evaluated the cytokine expression of splenic dendritic cells in chronic mouse toxoplasmosis by tissue cyst-forming Me49 strain and demonstrated the distribution of lymphoid dendritic cells by fluorescence-activated cell sorter (FACS). Pro-inflammatory cytokines, such as IL-$1{\alpha}$, IL-$1{\beta}$, IL-6, and IL-10 increased rapidly at week 1 post-infection (PI) and peaked at week 3 PI. Serum IL-10 level followed the similar patterns. FACS analysis showed that the number of $CD8{\alpha}^+/CD11c^+$ splenic dendritic cells increased at week 1 and peaked at week 3 PI. In conclusion, mouse splenic dendritic cells showed early and rapid cytokine changes and may have important protective roles in early phases of murine toxoplasmosis.

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