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생화학분자생물학회 (Korean Society for Biochemistry and Molecular Biology)
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Downregulation of Foxe1 by HR suppresses Msx1 expression in the hair follicles of HrHp mice

  • Choi, Jee-Hyun (Department of Biomedical Sciences, Research Institute of Molecular Genetics, College of Medicine, The Catholic University of Korea) ;
  • Kim, Byong-Kyu (Department of Biomedical Sciences, Research Institute of Molecular Genetics, College of Medicine, The Catholic University of Korea) ;
  • Kim, Jeong-Ki (Department of Biomedical Sciences, Research Institute of Molecular Genetics, College of Medicine, The Catholic University of Korea) ;
  • Lee, Hwa-Young (Department of Biomedical Sciences, Research Institute of Molecular Genetics, College of Medicine, The Catholic University of Korea) ;
  • Park, Jong-Keun (Department of Biomedical Sciences, Research Institute of Molecular Genetics, College of Medicine, The Catholic University of Korea) ;
  • KimYoon, Sung-Joo (Department of Biomedical Sciences, Research Institute of Molecular Genetics, College of Medicine, The Catholic University of Korea)
  • 투고 : 2011.05.12
  • 심사 : 2011.05.25
  • 발행 : 2011.07.31
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초록

Hairless (HR), a transcriptional cofactor, is highly expressed in the skin and brain. To characterize the effects of HR expression in the skin, we examined its capacity for transcriptional regulation of its target genes in mouse skin and keratinocytes. We found that Foxe1 mRNA expression was suppressed in HR-overexpressing skin, as well as in HR-expressing keratinocytes. In turn, Msx1 expression was downregulated contingent on Foxe1 downregulation in skin and keratinocytes. We also found that expression of Sfrp1 was also correlated with that of Foxe1. Further investigation of the mechanisms involved in the transcriptional regulation of these genes will facilitate our understanding of the relationship among genes involved in hair follicle morphogenesis and cycling.

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참고문헌

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피인용 문헌

  1. Hairless Plays a Role in Formation of Inner Root Sheath via Regulation ofDlx3Gene vol.287, pp.20, 2012, https://doi.org/10.1074/jbc.M111.320770
  2. Patterns of FOXE1 Expression in Papillary Thyroid Carcinoma by Immunohistochemistry vol.23, pp.7, 2013, https://doi.org/10.1089/thy.2012.0466
  3. Hairless down-regulates expression of Msx2 and its related target genes in hair follicles vol.71, pp.3, 2013, https://doi.org/10.1016/j.jdermsci.2013.04.019
  4. Exploration of the association between FOXE1 gene polymorphism and differentiated thyroid cancer: a meta-analysis vol.19, pp.1, 2018, https://doi.org/10.1186/s12881-018-0604-y